Negative Gonorrhea Test Results: What They Mean - Urology

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Questions about gonorrhea testing?


I recently went to a testing facility for a urine test to check for gonococcal DNA, and the result came back negative.
Does this mean that there is no gonococcal infection in my body? For example, does this rule out the possibility of gonococcal pharyngitis? After all, the result was negative.
Thank you, doctor.

M, 20~29 year old female. Ask Date: 2020/03/19

Dr. Du Shixi reply Urology


Hello: General tests cannot be 100% accurate.
To confirm, one should be asymptomatic, engage in safe behaviors, and have multiple negative test results.
Wishing you good health.

Reply Date: 2020/03/19

More Info


When you receive a negative gonorrhea test result, particularly from a nucleic acid amplification test (NAAT) that detects the DNA of Neisseria gonorrhoeae, it generally indicates that there is no active gonorrhea infection in the tested site. This is a reassuring outcome, especially if you have been experiencing symptoms or have had potential exposure to the infection.

However, it is important to understand the nuances of these results. A negative test result means that the specific sample taken (usually urine, but it can also be from a throat or rectal swab) did not show evidence of the gonorrhea bacteria. This is a strong indicator that you do not have an active infection at that site. For instance, if you were tested for gonorrhea in the throat and the result was negative, it is unlikely that you have gonococcal pharyngitis (throat infection caused by gonorrhea).

That said, there are a few important considerations to keep in mind:
1. Timing of the Test: If you were tested shortly after potential exposure to gonorrhea, it is possible that the infection may not have been detectable yet. The incubation period for gonorrhea can vary, and it may take several days to weeks for the bacteria to be present in detectable levels. If you suspect recent exposure, it may be advisable to retest after a week or two.

2. Sample Collection: The accuracy of the test can depend on how the sample was collected. If the sample was not taken correctly or if the site of infection was not tested (for example, if you have a throat infection but were only tested via urine), the result may not reflect the true status of your health. If you have symptoms in a different area, such as the throat or rectum, you should discuss this with your healthcare provider and consider testing those specific sites.

3. Other Infections: A negative gonorrhea test does not rule out other sexually transmitted infections (STIs). If you are experiencing symptoms such as sore throat, unusual discharge, or pain during urination, it is important to consider testing for other STIs, including chlamydia, syphilis, and HIV.

4. Follow-Up: If you have any ongoing symptoms or concerns, it is crucial to follow up with your healthcare provider. They can provide further evaluation, additional testing if necessary, and guidance on treatment or preventive measures.

In summary, a negative gonorrhea test result is a positive indication that you do not have an active gonorrhea infection at the tested site. However, if you have symptoms or concerns about potential exposure, it is wise to discuss these with your healthcare provider for further evaluation and possibly additional testing. Regular STI screenings are an important part of maintaining sexual health, especially if you have multiple partners or engage in high-risk behaviors.

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