Side Effects of Depression Medications: A Patient's Concern

Side Effects of Antidepressants

Hello Doctor: I take Efexor-XR 75mg (two capsules), Zyprexa Zydis 5mg (half a tablet), and Dormicum 7.5mg in the evening due to depression.
However, in the morning, I feel very sleepy, my hands tremble, and I have poor memory.
Are these symptoms considered normal? Thank you!

Mr. Huang, 40~49 year old female. Ask Date: 2020/04/24

Dr. Yu Quanxun reply Psychiatry

Hello, according to the precautions in the medication insert, the situations you mentioned could potentially be side effects of the medication, but they may also be residual symptoms of depression that have not fully improved.
Therefore, the presence of side effects is not the sole indicator for medication selection; improvement of symptoms and restoration of functional living are also crucial considerations in clinical practice when using medications.

Reply Date: 2020/04/24

More Info

When dealing with depression and the medications prescribed for its treatment, it is crucial to understand the potential side effects and how they can impact daily life. Your concerns about feeling excessively sleepy in the morning, experiencing hand tremors, and having memory issues after taking Efexor-XR (venlafaxine), Zyprexa Zydis (olanzapine), and Dormicum (midazolam) are valid and should be addressed with your healthcare provider.

Firstly, let's break down the medications you are taking:
1. Efexor-XR (Venlafaxine): This is a serotonin-norepinephrine reuptake inhibitor (SNRI) commonly used to treat depression and anxiety disorders. Side effects can include insomnia, dizziness, dry mouth, and in some cases, increased blood pressure. Some patients may also experience withdrawal symptoms if they miss a dose or stop taking it suddenly.

2. Zyprexa Zydis (Olanzapine): This medication is an atypical antipsychotic often used to treat mood disorders, including bipolar disorder and schizophrenia. Common side effects include sedation, weight gain, and metabolic changes. It can also cause extrapyramidal symptoms, which may manifest as tremors or other movement disorders.

3. Dormicum (Midazolam): This is a benzodiazepine used for its sedative properties. It can cause drowsiness, confusion, and memory impairment, especially if taken regularly or in higher doses.

Given that you are experiencing significant drowsiness in the morning, hand tremors, and memory issues, it is essential to consider the following:
- Drowsiness: This could be a side effect of Zyprexa or Dormicum, as both can cause sedation. If you are taking these medications at night, they may still be affecting you in the morning. Discuss with your doctor whether adjusting the timing of your doses or changing the medication might help alleviate this issue.

- Hand Tremors: This symptom could be related to Zyprexa, as it can cause movement disorders in some individuals. It is important to report this symptom to your healthcare provider, as they may need to adjust your medication or explore other treatment options.

- Memory Issues: Cognitive side effects can occur with both Zyprexa and Dormicum. If you find that your memory is significantly impaired, it is crucial to bring this up with your doctor. They may consider switching medications or adjusting dosages to minimize these effects.

It is also important to note that everyone's response to medication can vary widely. Some individuals may tolerate certain medications well, while others may experience significant side effects. Therefore, open communication with your healthcare provider is vital. They can help you weigh the benefits of your current treatment against the side effects you are experiencing.

In addition to medication management, consider incorporating lifestyle changes that can support your mental health. Regular physical activity, a balanced diet, adequate sleep, and mindfulness practices can all contribute to improved mood and overall well-being. Engaging in therapy, such as cognitive-behavioral therapy (CBT), can also provide you with tools to manage your symptoms and cope with the challenges of depression.

In summary, while some side effects may be common with the medications you are taking, the severity and impact on your daily life should be discussed with your healthcare provider. They can help you navigate these challenges and make necessary adjustments to your treatment plan. Remember, managing depression is often a multifaceted approach that includes medication, therapy, and lifestyle changes. Don't hesitate to reach out for support and advocate for your health.

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