Annual Pap Smear Concerns: Should I Get ThinPrep Testing After HPV Negative? - Obstetrics and Gynecology

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Pap smear examination shows inflammation every year?


Doctor, I have had traditional Pap smears every year, and each time I have inflammation with a result of grade 2, which raises concerns about a high rate of false negatives.
This year, feeling uneasy, I also underwent a Human Papillomavirus (HPV) test, and the result was negative for infection.
The clinic advised me that since I have no discomfort, I do not need to return for a follow-up.
Should I still consider getting a new type of liquid-based cytology test to determine the accuracy? The clinic told me that since I have no HPV infection, the risk of cervical cancer is very low and that I only need to have a Pap smear once a year.
However, I have a friend whose Pap smear results were also grade 2 for several years, and suddenly this year it turned into carcinoma in situ, which makes me anxious and worried.
Thank you.

ting, 30~39 year old female. Ask Date: 2020/06/27

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow the doctor's instructions.
Wishing you good health.

Reply Date: 2020/06/27

More Info


When it comes to cervical health and the management of HPV (Human Papillomavirus), it’s understandable to have concerns, especially after receiving a negative HPV test result and considering the implications of your Pap smear history. Let’s break down your situation and address your questions regarding ThinPrep testing, the significance of your HPV results, and the overall management of cervical health.

Firstly, it’s important to understand that a Pap smear is a screening test designed to detect abnormal cells in the cervix that could lead to cervical cancer. The ThinPrep method is a type of liquid-based cytology that can provide a clearer sample for examination compared to traditional Pap smears. It can also allow for concurrent HPV testing, which is beneficial in assessing the risk of cervical cancer.

In your case, you mentioned that you have had annual traditional Pap smears, and they have consistently shown inflammation with a grade of 2. This indicates the presence of some abnormal cells, but it does not necessarily mean you have cancer. The concern about false negatives is valid, especially if there is a history of abnormal results. However, the recent HPV test came back negative, which is a positive indicator. A negative HPV test significantly reduces the risk of developing cervical cancer, as high-risk HPV types are the primary cause of cervical cancer.

Your clinic’s recommendation to continue with annual Pap smears is in line with current guidelines, especially since your HPV test was negative. The risk of cervical cancer is indeed low in this scenario. However, your anxiety about the potential for sudden changes, as you mentioned with your friend’s experience, is understandable. It’s important to remember that while cervical cancer can develop, it typically takes years of persistent HPV infection and abnormal cell changes to progress to cancer.

Regarding whether you should pursue ThinPrep testing, it may be beneficial if you feel that your previous Pap smears have not provided clear results or if you have ongoing concerns about your cervical health. ThinPrep testing can sometimes yield more accurate results, especially in cases of inflammation or atypical cells. If you are feeling anxious about your current situation, discussing the option of ThinPrep testing with your healthcare provider could provide you with peace of mind.

In summary, based on your negative HPV test and the clinic’s advice, you may not need to rush into ThinPrep testing immediately. However, if you continue to have concerns or if your symptoms change, it would be wise to have a conversation with your healthcare provider about your options. Regular monitoring through Pap smears, combined with your negative HPV status, places you in a lower risk category for cervical cancer. Always trust your instincts about your health, and don’t hesitate to seek further testing if it will help alleviate your worries. Regular communication with your healthcare provider is key to managing your cervical health effectively.

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