Stevens-Johnson Syndrome Risks with Medications - Psychiatry

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Stevens-Johnson Syndrome


Before bedtime, I take 30mg of Cymbalta, 50mg of Seroquel, and two tablets of Effexor.
I would like to ask the doctor about the Cymbalta leaflet, which mentions the risk of causing fatal Stevens-Johnson syndrome.
After reading the leaflet, I am hesitant to take Cymbalta.
Is there a possibility of developing Stevens-Johnson syndrome? Thank you, doctor.

OO, 30~39 year old female. Ask Date: 2020/09/19

Dr. Huang Xiaoxian reply Psychiatry


Hello, the medication you are taking is relatively safe, and the likelihood of any issues is very low, so you can take it with peace of mind.
You may discuss it with your prescribing physician.
Wishing you well.

Reply Date: 2020/09/19

More Info


Stevens-Johnson Syndrome (SJS) is a serious and potentially life-threatening condition that primarily affects the skin and mucous membranes. It is often triggered by medications, infections, or other factors. The syndrome is characterized by the sudden onset of flu-like symptoms, followed by a painful rash that spreads and blisters, leading to the shedding of the skin. In severe cases, it can result in complications such as sepsis, organ failure, and even death.

When it comes to medications, certain drugs have been associated with an increased risk of developing SJS. These include some anticonvulsants, antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). The risk of SJS can vary based on individual factors, including genetic predisposition, the presence of other medical conditions, and the specific medication being used.

In your case, you mentioned taking medications such as 千憂解 (Trazodone), 思樂康 (Sertraline), and 美舒鬱 (Mirtazapine). While these medications can have side effects, the occurrence of SJS is relatively rare. However, it is essential to be aware of the potential risks associated with any medication. The package insert for 千憂解 may indicate the possibility of SJS, but this does not mean that everyone who takes it will develop the syndrome. The incidence of SJS with Trazodone is low, and many patients use it without experiencing severe adverse effects.

If you are concerned about the risk of SJS or any other serious side effects, it is crucial to discuss your worries with your healthcare provider. They can provide you with personalized advice based on your medical history, current medications, and overall health. Additionally, they can help you weigh the benefits of the medication against the potential risks.

It is also important to recognize the early signs of SJS. If you experience symptoms such as fever, sore throat, burning eyes, or a painful rash, you should seek medical attention immediately. Early intervention can be critical in managing the condition and preventing severe complications.

In summary, while the risk of Stevens-Johnson Syndrome exists with certain medications, it is relatively rare, and the benefits of treatment often outweigh the risks for many patients. Always communicate openly with your healthcare provider about any concerns you have regarding your medications, and do not hesitate to seek medical advice if you notice any unusual symptoms. Your health and safety are paramount, and your doctor can help you navigate these concerns effectively.

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