Interactions Between Betahistine, Diazepam, and Birth Control Pills - Obstetrics and Gynecology

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Betahistine, Diazepam, and Oral Contraceptives?


Hello, doctor.
I have been taking the contraceptive pill "Aydin" every night before bed for three years.
Currently, I am experiencing dizziness and am taking F38 Betahistine HCL 24mg after breakfast and dinner, and Diazepam 2mg before bed.
I would like to ask: 1.
Can I take Diazepam at bedtime together with the contraceptive pill? If not, how long should I wait between taking them? 2.
Do these two medications interact with the contraceptive pill, and will they affect its contraceptive effectiveness? Thank you, doctor!

Niming, 30~39 year old female. Ask Date: 2020/11/07

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
It is recommended to wait half an hour before eating.
Wishing you good health.

Reply Date: 2020/11/07

More Info


When considering the interactions between Betahistine, Diazepam, and birth control pills, it's essential to understand how these medications work and their potential effects on each other.

1. Can Diazepam be taken with birth control pills?
Diazepam, a benzodiazepine, is often prescribed for anxiety, muscle spasms, and sleep disorders. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, leading to a calming effect. Birth control pills, such as "愛逸定" (which contains ethinyl estradiol and a progestin), primarily function by regulating hormones to prevent ovulation.

While there is no direct contraindication for taking Diazepam and birth control pills together, it is generally recommended to space them out to minimize any potential side effects, particularly the increased risk of sedation or dizziness. A common recommendation is to wait at least 30 minutes between taking these medications. This allows the body to process each medication more effectively and reduces the likelihood of compounded side effects.

2. Do these medications interact with birth control pills and affect their efficacy?
In general, Diazepam does not significantly affect the efficacy of hormonal contraceptives like birth control pills. The primary concern with Diazepam is its sedative effects, which can be enhanced when combined with other central nervous system depressants. However, it does not interfere with the hormonal mechanisms of birth control pills.

On the other hand, Betahistine, which is often used to treat vertigo and balance disorders, also does not have a known interaction with hormonal contraceptives. It works by improving blood flow in the inner ear, which can help alleviate symptoms of dizziness. Therefore, both Betahistine and Diazepam are not expected to compromise the effectiveness of your birth control pills.

Additional Considerations:
While the interactions between these medications are minimal, it is crucial to monitor for any side effects. Diazepam can cause drowsiness, dizziness, and impaired coordination, which may be exacerbated when taken with other medications that have sedative properties. If you experience increased sedation or any unusual symptoms, it is advisable to consult your healthcare provider.

Moreover, if you are taking multiple medications, it is always wise to inform your healthcare provider about all the medications you are using, including over-the-counter drugs and supplements. This ensures that they can provide you with the best advice tailored to your health needs.

In summary, while Diazepam and Betahistine can be taken alongside birth control pills without significant interaction, spacing out the doses is recommended to minimize side effects. Always consult with your healthcare provider for personalized advice and to discuss any concerns regarding your medications.

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