Managing Ventricular Premature Contractions: Medication Consultation Insights - Psychiatry

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Ventricular premature contractions, medication consultation?


Hello, Doctor.
I am experiencing ventricular contractions caused by autonomic nervous system dysregulation.
I am currently taking 20 mg of Prozac (fluoxetine) twice a day and half a 5 mg tablet of Nortriptyline.
Is this dosage considered high? Does Prozac have a curative effect? Can taking it for a period of time help regulate the autonomic nervous system? Thank you.

Xiao Yi, 20~29 year old female. Ask Date: 2020/11/24

Dr. Liao Dinglie reply Psychiatry


Hello, user: The autonomic nervous system dysfunction has led to ventricular premature contractions (VPC).
You are using Prozac (fluoxetine) and Nortriptyline, and it seems you have already undergone evaluations related to your heart and received psychiatric treatment.

Regarding your first question (medication dosage): A dosage of 40 mg/day of Prozac is a common dosage and is not considered high.
The 2.5 mg/day of Nortriptyline is only half of the typical starting dose for adults.

For your second question (the role of Prozac in treatment): It is usually necessary to discuss treatment goals with your primary physician, whether they are for short-term treatment, ongoing treatment, prevention of relapse, or other objectives.
Prozac can be used at various stages of disease treatment or relapse prevention.

As for your third question (whether autonomic nervous system regulation is possible): If the treatment goal is to reduce arrhythmias, it should be possible to quantitatively assess whether the frequency of arrhythmias has decreased.
After achieving significant therapeutic effects, please discuss with your primary physician whether to continue medication for a period to enhance the stability of the autonomic nervous system, to avoid relapse after discontinuation, or to use other non-pharmacological methods to assist in gradually stabilizing the autonomic nervous system.

Dr.
Liao Ding-Lie

Reply Date: 2020/11/24

More Info


Managing ventricular premature contractions (VPCs) can be a complex process, especially when considering the underlying causes such as autonomic nervous system dysregulation. Your current medication regimen includes two 20 mg doses of Prozac (Fluoxetine) and half a 5 mg dose of Nortriptyline (Nadiflox).
Firstly, let's address the dosages. Fluoxetine is typically prescribed in doses ranging from 20 mg to 80 mg per day, depending on the condition being treated. Therefore, taking 40 mg (two 20 mg capsules) is within the standard therapeutic range for many conditions, including depression and anxiety disorders. Nortriptyline, on the other hand, is often prescribed in doses of 25 mg to 150 mg per day, so your dose of 2.5 mg (half of a 5 mg tablet) is quite low. This combination of medications can be effective for managing anxiety and depression, which may indirectly help with the symptoms of VPCs, particularly if they are exacerbated by stress or anxiety.

Regarding the question of whether Prozac has a "curative" effect, it is important to understand that while it can help alleviate symptoms of anxiety and depression, it does not directly address the underlying autonomic dysregulation. Instead, it works by increasing serotonin levels in the brain, which can improve mood and reduce anxiety. This, in turn, may help reduce the frequency of VPCs if they are related to anxiety. However, it is not a cure for the underlying condition itself.

As for the potential for these medications to "regulate" the autonomic nervous system, it is important to note that while they can help manage symptoms, they may not necessarily restore balance to the autonomic nervous system. Lifestyle modifications, such as stress management techniques, regular exercise, adequate sleep, and a healthy diet, are also crucial components in managing autonomic dysregulation. Some patients find that cognitive-behavioral therapy (CBT) or other forms of psychotherapy can be beneficial in addressing the psychological aspects of their condition.

In terms of duration, it can take several weeks to months for the full effects of medications like Prozac to be felt, and ongoing management may be necessary. Regular follow-ups with your healthcare provider are essential to monitor your symptoms, adjust dosages if necessary, and evaluate the effectiveness of your treatment plan.

In conclusion, while your current medication regimen is within standard dosing guidelines, it is essential to have a comprehensive approach to managing your condition. This includes regular consultations with your healthcare provider, lifestyle modifications, and possibly exploring additional therapies that may help regulate your autonomic nervous system. If you have concerns about your medication or its effects, do not hesitate to discuss them with your healthcare provider, who can provide personalized guidance based on your specific situation.

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