Is It Safe to Use Muscle Relaxant Capsules During Early Pregnancy? - Obstetrics and Gynecology

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Is it safe to use Shujitong capsules during early pregnancy?


Hello Doctor: As per the title, this medication seems to lack clear classification in terms of drug scheduling.
I looked it up and found that it is a compound formulation, so I researched each ingredient.
It contains b and c; should it be avoided? Thank you for your response.
Here are the ingredient details: Acetaminophen 250mg, Chlorzoxazone 150mg, Caffeine Anhydrous 20mg, Thiamine disulfide 7.7mg.

Liu Tai Tai, 30~39 year old female. Ask Date: 2021/03/16

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, theoretically it should not have any impact.
Wishing you good health.

Reply Date: 2021/03/16

More Info


When considering the safety of using muscle relaxants during early pregnancy, it is essential to evaluate the specific components of the medication and their classifications according to the FDA's pregnancy categories. In your case, the muscle relaxant capsule contains Acetaminophen, Chlorzoxazone, Caffeine Anhydrous, and Thiamine Disulfide.
1. Acetaminophen (250 mg): This is classified as Category B. Studies have shown that it does not pose a risk to the fetus when used at recommended doses. It is commonly used for pain relief and is generally considered safe during pregnancy.

2. Chlorzoxazone (150 mg): This muscle relaxant is classified as Category C. This means that there are no adequate studies in pregnant women, and animal studies have shown an adverse effect on the fetus. However, it may be prescribed if the potential benefits justify the potential risks to the fetus. Given its classification, it is advisable to use caution and consult with your healthcare provider before continuing its use.

3. Caffeine Anhydrous (20 mg): Caffeine is also classified as Category C. While moderate caffeine consumption (up to 200 mg per day) is generally considered safe during pregnancy, excessive intake can lead to complications such as low birth weight or miscarriage. The amount in your muscle relaxant is relatively low, but it’s still important to monitor total caffeine intake from all sources.

4. Thiamine Disulfide (7.7 mg): This is a form of vitamin B1 and is generally considered safe during pregnancy. It is often included in formulations to support overall health and metabolism.

Given the combination of these ingredients, the presence of Chlorzoxazone as a Category C drug raises concerns. While Acetaminophen is considered safe, the uncertainty surrounding Chlorzoxazone means that it should be used with caution, especially in the first trimester when the risk of teratogenic effects is highest.

Recommendations:
- Consult Your Healthcare Provider: It is crucial to discuss with your healthcare provider whether the benefits of using this muscle relaxant outweigh the potential risks. They may suggest alternative treatments or therapies that are safer during pregnancy.

- Consider Non-Pharmacological Approaches: If muscle tension or discomfort is the issue, consider non-drug interventions such as physical therapy, gentle stretching, prenatal yoga, or relaxation techniques. These methods can often provide relief without the risks associated with medication.

- Monitor Symptoms: If your symptoms are mild, it may be worth considering whether you can manage without medication. If you find that your discomfort is manageable, it might be best to avoid the muscle relaxant altogether.

In conclusion, while Acetaminophen is generally safe, the presence of Chlorzoxazone as a Category C drug means that caution is warranted. Always prioritize discussions with your healthcare provider to ensure the safety of both you and your developing baby.

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