Cervical Pre-Cancer: Concerns and HPV Insights - Obstetrics and Gynecology

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Cervical precancerous lesions


Hello Doctor, last year I had an abnormal Pap smear and tested positive for HPV type 33.
After a year of monitoring, my condition worsened from CIN1 to CIN2 and CIN3, so the hospital arranged for an LLETZ procedure.
I am feeling very anxious and afraid that I might have cancer and eventually need a hysterectomy.
For the past few years, I have also felt a persistent fullness in my right groin area.
There are no visible lumps, and I can't feel anything when I press on it, but it feels full, especially when lying flat or stretching, which gives me a pulling sensation.
Could this be a symptom of cancer metastasis, or is the HPV virus attacking my groin lymph nodes? If that is the case, will the surgery help improve this sensation? Additionally, I had a history of hernia in elementary school, but I did not have surgery, and it healed naturally as I grew up.
However, I feel that this fullness is different from the hernia.
Also, after the surgery, when would it be appropriate to receive the HPV vaccine? I actually received the vaccine seven years ago, but it seems that it did not protect against type 33...
Thank you for your clarification; I am really feeling very uneasy.

F, 30~39 year old female. Ask Date: 2021/03/26

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the groin area should not be significantly related to cervical cancer.
If you are still feeling unwell, you can consult a surgeon.
If you wish to receive the vaccine, you can certainly do so without waiting.
Wishing you good health.

Reply Date: 2021/03/26

More Info


Understanding cervical pre-cancer, particularly in the context of HPV (human papillomavirus) infections, can be a source of anxiety for many individuals. Your concerns regarding the progression from CIN (cervical intraepithelial neoplasia) 1 to CIN 2 and CIN 3, as well as the potential for cancer and its implications, are valid and deserve careful consideration.

Firstly, it's important to understand the relationship between HPV and cervical cancer. HPV is a common sexually transmitted infection, and certain high-risk types, including HPV 16 and 18, are known to be associated with the development of cervical cancer. HPV 33, while not as prevalent as 16 or 18, is still considered a high-risk type. The progression from HPV infection to cervical cancer typically involves several stages: initial infection, persistence of the virus, development of pre-cancerous lesions (CIN 1, CIN 2, CIN 3), and eventually invasive cancer if left untreated.
Regarding your specific situation, the progression from CIN 1 to CIN 2 and then to CIN 3 indicates that the abnormal cells are becoming more severe. The LLETZ (Large Loop Excision of the Transformation Zone) procedure you are scheduled for is a common treatment for removing these pre-cancerous cells and is generally effective in preventing the progression to cervical cancer.
Your concern about the sensation of fullness or pressure in your right groin area is understandable. While it is possible for cervical cancer to metastasize (spread) to lymph nodes in the groin, this typically occurs in more advanced stages of the disease. The symptoms you describe—such as a feeling of fullness or pulling sensation—could be related to various factors, including lymphatic congestion, previous hernia issues, or even anxiety. It is less likely that these symptoms are directly caused by HPV attacking your lymph nodes, especially if you have not experienced any significant changes in your health or physical examination findings.

After your LLETZ procedure, it is crucial to follow up with your healthcare provider for regular monitoring. This will help ensure that any remaining abnormal cells are addressed promptly. As for the HPV vaccine, it is recommended to receive it even after previous infections, as it can protect against other strains of HPV that you may not have been exposed to. Generally, it is advisable to wait until you have fully recovered from surgery before getting vaccinated, which could be a few months post-procedure.
In summary, while it is natural to feel anxious about the potential for cancer, the steps you are taking—such as undergoing LLETZ and considering vaccination—are proactive measures that can significantly reduce your risk. It is essential to maintain open communication with your healthcare provider, who can provide personalized advice and reassurance based on your specific circumstances. Regular follow-ups and screenings will be key in managing your health moving forward. Remember, early detection and treatment are crucial in effectively managing cervical pre-cancer and preventing the development of cervical cancer.

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