Combining Anzepam and Cerenin: Safety and Side Effects Explained - Pharmacology

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Follow-up questions after taking Anzepam?


I apologize for not mentioning earlier that after my last outpatient visit, the doctor prescribed CERENIN (which seems to be Ginkgo biloba).
Since I was only advised to try it, I am a bit concerned.
I would like to know if there are any issues or side effects associated with taking these two medications together.
Thank you.

William, 30~39 year old female. Ask Date: 2003/03/04

Dr. Liu Huiya reply Pharmacology


Hello William: The medication Cerenin (Ginkgo biloba extract, 40mg) is an extract from the Ginkgo tree, approved by the Ministry of Health in Taiwan for the indication of "improving peripheral blood circulation disorders." Since the 1970s, Europe has been actively researching Ginkgo leaves, using their extracts to treat symptoms such as amnesia, tinnitus, dizziness, and poor blood circulation.
Currently, it holds a place in both prescription medications and dietary supplements in various countries in Europe and America.
At the recommended dosage (daily dosage range: 40mg to 150mg), Cerenin has mild side effects, which include headaches, gastrointestinal disturbances, and some skin allergic reactions, with very few reports of cardiovascular side effects.
However, caution should be exercised to avoid concurrent use with aspirin or anticoagulant medications.
Combining Ginkgo with aspirin may prolong bleeding time and increase the risk of excessive bleeding.
Therefore, individuals with platelet function disorders, blood cancers, pregnant women, patients post-surgery (including tooth extraction), and women during menstruation should avoid using Ginkgo leaves to prevent potential bleeding complications.
As for concurrent use with benzodiazepines, current data suggests there are no interaction issues.

Reply Date: 2003/03/04

More Info


When considering the combination of Anzepam (a brand name for lorazepam) and Cerenin (a ginkgo biloba extract), it is essential to understand the pharmacological profiles of both medications and their potential interactions.
Anzepam, which is a benzodiazepine, is primarily used for its anxiolytic (anti-anxiety), sedative, and muscle relaxant properties. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, leading to a calming effect. Common side effects of lorazepam include drowsiness, dizziness, and potential dependency with long-term use.

Cerenin, on the other hand, is derived from ginkgo biloba leaves and is often used to improve peripheral blood circulation and cognitive function. It has been studied for its potential benefits in conditions like memory impairment, tinnitus, and dizziness. While Cerenin is generally well-tolerated, it can cause mild side effects such as headaches, gastrointestinal disturbances, and allergic skin reactions. Importantly, ginkgo biloba can interact with anticoagulants (like aspirin) and may increase the risk of bleeding due to its blood-thinning properties.

Regarding the combination of Anzepam and Cerenin, current evidence suggests that there are no significant drug interactions between these two medications. This means that, when taken together, they are unlikely to produce adverse effects or diminish each other's efficacy. However, it is always prudent to monitor for any unusual symptoms when starting a new medication, especially if you are already on other treatments.

While the combination is considered safe, there are a few considerations to keep in mind:
1. Individual Response: Each person may react differently to medications. While one individual may not experience any side effects, another might have an adverse reaction. It is essential to pay attention to how your body responds when starting Cerenin alongside Anzepam.

2. Underlying Conditions: If you have any pre-existing health conditions, particularly those related to bleeding disorders, liver function, or mental health issues, it is crucial to discuss these with your healthcare provider. They can provide personalized advice based on your medical history.

3. Dosage and Duration: The dosage of both medications should be adhered to as prescribed by your healthcare provider. Avoid self-medicating or adjusting dosages without consulting your doctor, as this can lead to increased side effects or reduced effectiveness.

4. Monitoring for Side Effects: While the combination is generally safe, be vigilant for any signs of excessive sedation, unusual bleeding, or other concerning symptoms. If you experience any severe side effects, contact your healthcare provider immediately.

5. Consult Your Doctor: Since your doctor prescribed Cerenin, it is advisable to discuss any concerns you have about combining it with Anzepam directly with them. They can provide reassurance and additional information tailored to your specific situation.

In summary, combining Anzepam and Cerenin is generally considered safe, with no significant interactions reported. However, individual responses can vary, and it is essential to monitor for any side effects and maintain open communication with your healthcare provider. Always prioritize your health and safety by following medical advice and reporting any concerns you may have.

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