Antibiotic Side Effects: Diarrhea and Skin Rashes - Gastroenterology and Hepatology

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Diarrhea after taking antibiotics?


Hello, doctor.
Recently, I had sinusitis and took antibiotics for almost three weeks.
My sinusitis has improved, and after finishing the antibiotics, I didn't go back to see the doctor.
However, it's been almost a week since I stopped the antibiotics, and I have been experiencing diarrhea several times a day.
I also have developed rashes on my skin.
Could this be a side effect of the antibiotics?

Skyy, 30~39 year old female. Ask Date: 2021/04/22

Dr. Yang Zhichao reply Gastroenterology and Hepatology


Hello Mr.
Skyy, due to the wide variety of antibiotics, some are indeed associated with diarrhea or can alter gut microbiota, leading to diarrhea.
Skin rashes may be an allergic reaction; if you notice a rash, you should immediately consult your prescribing physician to avoid a severe allergic reaction if you need to take the medication again in the future.
Thank you for your question.

Reply Date: 2021/04/22

More Info


Hello! It sounds like you are experiencing some concerning symptoms after completing a course of antibiotics for your sinus infection. Let's break down your situation and discuss the potential side effects of antibiotics, particularly focusing on diarrhea and skin rashes.

Antibiotics are powerful medications used to treat bacterial infections, but they can also disrupt the balance of bacteria in your gut. This disruption can lead to gastrointestinal side effects, the most common of which is diarrhea. When antibiotics kill harmful bacteria, they can also affect beneficial bacteria in the intestines, leading to an overgrowth of other organisms, such as Clostridium difficile (C. diff), which can cause severe diarrhea. This condition is known as antibiotic-associated diarrhea and can occur even after you have finished your antibiotic course, as the gut may take some time to recover.

In your case, experiencing diarrhea for nearly a week after stopping the antibiotics suggests that your gut flora may still be out of balance. It's essential to stay hydrated during this time, as diarrhea can lead to dehydration. If the diarrhea persists or worsens, or if you experience additional symptoms such as fever, abdominal pain, or blood in your stool, it is crucial to seek medical attention promptly.

Regarding the skin rashes you mentioned, antibiotics can also cause allergic reactions in some individuals. These reactions can manifest as rashes, hives, or other skin irritations. If the rash is itchy, red, or spreading, it could indicate an allergic response to the antibiotic you were prescribed. In some cases, skin rashes can also be a sign of a more severe reaction, such as Stevens-Johnson syndrome, although this is rare. If you notice any swelling, difficulty breathing, or other severe symptoms, you should seek immediate medical help.

It's worth noting that not all antibiotics cause these side effects, and individual reactions can vary widely. Some people may tolerate antibiotics well without any adverse effects, while others may experience significant gastrointestinal or dermatological issues.

To manage your current symptoms, consider the following recommendations:
1. Probiotics: Taking probiotics may help restore the balance of good bacteria in your gut. Probiotics can be found in yogurt, fermented foods, or as dietary supplements. They may help reduce antibiotic-associated diarrhea.

2. Hydration: Ensure you are drinking plenty of fluids to stay hydrated, especially if you are experiencing diarrhea.

3. Diet: Eating a bland diet (such as bananas, rice, applesauce, and toast) may help ease gastrointestinal discomfort. Avoid spicy, fatty, or high-fiber foods until your symptoms improve.

4. Monitor Your Symptoms: Keep track of your symptoms, including the frequency and consistency of your diarrhea and the nature of your skin rash. If symptoms persist or worsen, consult your healthcare provider.

5. Consult Your Doctor: Given your ongoing symptoms, it would be wise to follow up with your healthcare provider. They may want to evaluate your condition further, possibly testing for C. difficile or considering alternative treatments for your skin rash.

In summary, while diarrhea and skin rashes can be side effects of antibiotics, they can also indicate other underlying issues. It’s essential to monitor your symptoms closely and seek medical advice if they do not resolve or if you experience any alarming signs. Your health and well-being are paramount, so don’t hesitate to reach out to your healthcare provider for guidance.

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