Post-AZ Vaccine: Mild Thigh Pain and Blood Circulation Concerns - Internal Medicine

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Mild intermittent pain in the front of the left thigh three to four days after receiving the AZ vaccine?


Hello, I received the AZ vaccine 3-4 days ago, and since last night, I've been experiencing intermittent pain in the front of my left thigh.
The pain does not persist continuously; it sometimes suddenly disappears, and the intensity is similar to cramping, which is bearable.
It currently does not affect my ability to walk, but I feel that the blood circulation in my leg seems to have worsened, as I am experiencing numbness more easily than usual.
Although I occasionally experience numbness in my legs from sitting for long periods, I have never had this kind of intermittent sharp pain before.
Additionally, I noticed that the vaccine information mentioned a risk of thrombosis if there is pain in the lower limbs after vaccination.
Therefore, I would like to ask if, despite the pain being manageable, I should go to the hospital to check for the possibility of a blood clot.
Thank you.

Niming, 30~39 year old female. Ask Date: 2021/07/29

Dr. Hong Yuanbin reply Internal Medicine


Hello, based on your timeline and symptoms, it is likely that the foot pain is not caused by a thrombus related to the AZ vaccine.
However, if the discomfort persists, you may consider consulting an orthopedic or neurology specialist to identify the underlying cause.
Thank you for your inquiry.

Reply Date: 2021/07/29

More Info


Post-vaccination symptoms can often be concerning, especially when they involve unusual pain or sensations in the limbs. In your case, experiencing intermittent pain in the left thigh along with feelings of reduced blood circulation after receiving the AstraZeneca (AZ) vaccine warrants careful consideration.

Firstly, it is important to understand that the AZ vaccine, like many others, can cause a range of side effects. Commonly reported side effects include fever, fatigue, headache, and muscle pain, which typically resolve within a few days. However, there are rare but serious side effects associated with the AZ vaccine, such as Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT), which involves blood clots and low platelet counts. The incidence of VITT is estimated to be around 1 in 100,000 doses, primarily occurring within 4 to 28 days post-vaccination.

Your description of the thigh pain resembling cramps, along with sensations of numbness or tingling, could be indicative of several conditions. While it is possible that these symptoms are simply a benign reaction to the vaccine, it is prudent to remain vigilant for signs that could suggest a more serious issue, such as a blood clot. Symptoms of a blood clot in the leg (deep vein thrombosis, or DVT) can include:
1. Swelling in one leg (not both).

2. Pain or tenderness that may feel like cramping or soreness.

3. A warm sensation in the affected area.

4. Changes in skin color, such as redness or a bluish tint.

Given that you mentioned the pain is not severe and does not hinder your ability to walk, it may not be an immediate cause for alarm. However, the fact that you are experiencing unusual sensations, particularly in the context of recent vaccination, means it is wise to consult a healthcare professional for further evaluation.

If you decide to seek medical attention, it would be appropriate to visit a primary care physician or a specialist in vascular medicine. They may recommend diagnostic tests such as an ultrasound to assess blood flow in the affected leg and to rule out the presence of a clot. Additionally, blood tests may be performed to evaluate your platelet levels and other markers that could indicate clotting issues.

In the meantime, consider the following self-care measures:
- Stay active and avoid prolonged periods of immobility, as this can help promote circulation.

- Elevate your leg when resting to reduce any swelling.

- Stay hydrated, as proper hydration can support overall vascular health.

- Monitor your symptoms closely; if they worsen or if you develop new symptoms such as swelling, redness, or increased pain, seek medical attention promptly.

In conclusion, while your symptoms may not currently indicate a serious condition, it is essential to remain cautious and proactive about your health. Consulting with a healthcare provider will provide you with the best guidance tailored to your specific situation. Remember, it is always better to err on the side of caution when it comes to potential post-vaccination complications.

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