Medication Interactions After Vaccination and Kidney Health - Gastroenterology and Hepatology

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Hello, doctor: I received the High-End vaccine yesterday morning, and in the evening, I took a Tylenol due to stomach discomfort.
There have been reports suggesting that it is best not to take anti-inflammatory medications after vaccination to avoid affecting the vaccine's efficacy.
Is Tylenol considered an anti-inflammatory medication? Additionally, my family member is taking Pepto-Bismol; does this medication have any harmful effects on the kidneys?

Azheng, 30~39 year old female. Ask Date: 2021/09/10

Dr. Chen Shidian reply Gastroenterology and Hepatology


Stomach medications are not anti-inflammatory drugs.
Stomach medications do not harm the kidneys.

Reply Date: 2021/09/10

More Info


When it comes to understanding medication interactions, especially after vaccination, it's essential to consider both the type of medication taken and the individual's overall health, particularly kidney function.
First, regarding your question about the medication you took after receiving the vaccine, "息痛佳音錠" (which contains acetaminophen, also known as paracetamol) is primarily a pain reliever and fever reducer rather than a traditional anti-inflammatory drug. While it does not have significant anti-inflammatory properties like NSAIDs (non-steroidal anti-inflammatory drugs), it can still be used to manage discomfort or fever that may arise after vaccination. Current guidelines generally suggest that if you experience mild side effects from a vaccine, such as fever or pain, it is acceptable to take acetaminophen to alleviate these symptoms. However, it is advisable to avoid taking NSAIDs immediately after vaccination unless necessary, as they may potentially interfere with the immune response.

As for the medication "百抑潰" (which is likely a reference to a medication used for gastrointestinal issues, such as a proton pump inhibitor or an antacid), the impact on kidney health can vary depending on the specific formulation and the individual's health status. Some studies have indicated that long-term use of certain gastrointestinal medications, particularly proton pump inhibitors, may be associated with an increased risk of kidney disease. However, this risk is generally more pronounced with prolonged use rather than short-term use.
Given your family member's kidney health history, it is crucial to monitor kidney function regularly, especially if they are on multiple medications. The kidneys are responsible for filtering out waste products and medications from the bloodstream, and certain drugs can be nephrotoxic (harmful to the kidneys). It is always wise to consult with a healthcare provider regarding the safety of any medications, particularly for individuals with a history of kidney issues.

In summary, while acetaminophen is generally safe to use after vaccination, it is essential to be cautious with other medications, especially in individuals with compromised kidney function. Regular monitoring of kidney health and open communication with healthcare providers about all medications being taken is crucial for maintaining overall health and preventing potential complications. If there are any concerns about kidney function or medication interactions, a visit to a healthcare professional for a thorough evaluation and personalized advice is recommended.

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