Impact of Vaccination on Endometriosis Treatment: Your Questions Answered - Obstetrics and Gynecology

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Vaccine Anaphylaxis


Hello doctor, I had surgery for a 10 cm chocolate cyst at the end of March this year.
After receiving two doses of long-acting Decapeptyl, I started taking Esmya.
The second dose of Decapeptyl was administered on July 10.
Should I start taking Esmya on October 10? Will my menstruation be irregular as a result? I plan to get vaccinated (BNT) on October 8.
Will this affect my ability to start Esmya on October 10? Should I wait a few days before starting Esmya? Thank you.

Zi, 30~39 year old female. Ask Date: 2021/10/01

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow your physician's instructions.
Take the medication Epinastine; everyone's response varies.
Some individuals may experience slight bleeding, while others may not, and this is unrelated to vaccination.
Wishing you good health.

Reply Date: 2021/10/01

More Info


When considering the impact of vaccination on endometriosis treatment, particularly in the context of your situation involving the use of long-acting medications like Diphereline and the introduction of a new medication, it is essential to understand how these factors interact.

Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus, often leading to pain, irregular bleeding, and fertility issues. Treatments typically include hormonal therapies aimed at reducing estrogen levels, which can exacerbate the condition. Diphereline (a GnRH agonist) is commonly used to suppress ovarian function and lower estrogen levels, thereby helping to manage endometriosis symptoms.

In your case, you mentioned that you had surgery for a 10 cm chocolate cyst (a type of endometriosis) and have been receiving Diphereline injections. After your second injection on July 10, you are considering starting a new medication, "Yasmin" (which is a combined oral contraceptive), on October 10, following your vaccination with the BNT vaccine on October 8.

1. Timing of Medication: It is generally advisable to maintain a consistent schedule with your hormonal treatments. Starting Yasmin on October 10 after your vaccination should not pose significant risks. Vaccines like BNT (Pfizer-BioNTech) are designed to stimulate the immune system and do not interfere with hormonal medications. However, some individuals may experience mild side effects from the vaccine, such as fatigue or low-grade fever, which could temporarily affect how you feel.

2. Menstrual Cycle Changes: The introduction of Yasmin after Diphereline can lead to changes in your menstrual cycle. Yasmin is designed to regulate menstrual cycles and may help alleviate some symptoms associated with endometriosis. However, since Diphereline suppresses menstruation, you might experience some irregularities as your body adjusts to the new medication. It is not uncommon for women transitioning between these treatments to have fluctuations in their menstrual patterns.

3. Consulting Your Healthcare Provider: It is crucial to communicate with your healthcare provider regarding your vaccination and medication schedule. They can provide personalized advice based on your medical history and current treatment plan. If you have concerns about starting Yasmin immediately after vaccination, your doctor may suggest waiting a few days, but this is typically not necessary.

4. Overall Health Considerations: Both endometriosis and the treatments for it can impact your overall health. It is essential to monitor how you feel after receiving the vaccine and starting new medications. If you experience any unusual symptoms or side effects, reach out to your healthcare provider for guidance.

In summary, receiving the BNT vaccine should not negatively impact your ability to start Yasmin on October 10. Your menstrual cycle may experience some irregularities as your body adjusts to the hormonal changes, but this is a normal part of transitioning between treatments. Always consult with your healthcare provider for tailored advice and to ensure that your treatment plan is optimal for your health and well-being.

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