Impact of Povidone-Iodine Use During Pregnancy: Concerns for First-Time Parents - Obstetrics and Gynecology

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Use of Povidone-Iodine for Trauma During Pregnancy


During the 20-26 week period of my wife's pregnancy, she experienced two minor cuts to her fingernail (the wound area was small).
We used povidone-iodine for disinfection and antisepsis (approximately four times, each application lasting about 5-10 minutes).
Later, we discovered that povidone-iodine is classified as a Category D medication and should not be used.
I would like to ask the doctor how significant the impact of this might be.
As first-time parents, we are quite worried.

Boka, 30~39 year old female. Ask Date: 2021/10/07

Dr. Huang Yiwen reply Obstetrics and Gynecology


Hello Mr.
Boka: During pregnancy, using ointments for external injuries does not have an impact on the baby, so there is no need to worry too much.
In clinical practice, most medications used for pregnant women are classified as Category D, which means that while animal studies may show harmful effects, there is no evidence to support that they are harmful to humans.

Reply Date: 2021/10/07

More Info


The use of Povidone-Iodine (commonly known as Betadine) during pregnancy raises valid concerns, especially for first-time parents who are understandably anxious about the health of their unborn child. Povidone-Iodine is classified as a Category D drug by the FDA, indicating that there is evidence of risk to the fetus based on human data, but the potential benefits may warrant its use in certain situations despite the risks.

In your case, the application of Povidone-Iodine for minor cuts on your wife's fingers during the 20-26 week period of pregnancy is a situation that requires careful consideration. While Povidone-Iodine is effective as an antiseptic and is often used to prevent infections, its use during pregnancy should be limited and approached with caution.


Potential Risks
1. Thyroid Function: One of the primary concerns with Povidone-Iodine is its iodine content, which can affect thyroid function in both the mother and the fetus. Excessive iodine exposure can lead to thyroid dysfunction, which may result in conditions such as hypothyroidism or hyperthyroidism. This is particularly concerning during pregnancy when the thyroid plays a crucial role in fetal development.

2. Skin Absorption: Although the amount of Povidone-Iodine absorbed through the skin is generally low, repeated applications, especially over larger areas or for extended periods, could increase systemic absorption. This could potentially lead to adverse effects on fetal development, particularly in the thyroid.

3. Allergic Reactions: Some individuals may experience allergic reactions to iodine-based products, which could complicate the healing process of the wound.


Recommendations
1. Consult a Healthcare Provider: It is essential to discuss your concerns with a healthcare provider who can assess the specific circumstances of your wife's use of Povidone-Iodine. They may recommend monitoring thyroid function or other assessments to ensure that both the mother and the fetus are healthy.

2. Limit Use: For future minor injuries, consider using alternative antiseptics that are classified as safer during pregnancy, such as saline solutions or alcohol-based hand sanitizers, which do not carry the same risks as iodine-based products.

3. Monitor for Symptoms: Keep an eye out for any symptoms that may indicate thyroid issues, such as fatigue, weight changes, or changes in mood. If any concerning symptoms arise, seek medical attention promptly.

4. Follow-Up Care: If there are ongoing concerns about the impact of Povidone-Iodine on the pregnancy, consider scheduling a follow-up appointment with a specialist, such as an obstetrician or a maternal-fetal medicine expert, who can provide tailored advice and care.


Conclusion
While the use of Povidone-Iodine during pregnancy is not without risks, the actual impact on your wife's pregnancy will depend on various factors, including the frequency of use, the amount applied, and the individual response to the antiseptic. It is crucial to maintain open communication with healthcare providers and to prioritize the health and safety of both the mother and the unborn child. The anxiety of first-time parents is completely normal, and seeking reassurance and guidance from medical professionals can help alleviate some of those concerns.

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