Are These Supplements Food or Drugs? Daily Dosage Recommendations - Pharmacology

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L-Glutamine


L-Glutamine, L-Arginine, L-Phenylalanine, L-Theanine, BCAA (Branched-Chain Amino Acids), and L-Lysine are generally classified as dietary supplements rather than pharmaceuticals.

The recommended daily dosages can vary based on individual needs, health conditions, and specific goals, but general guidelines are as follows:
- L-Glutamine: 5-10 grams per day
- L-Arginine: 2-6 grams per day
- L-Phenylalanine: 500-1,500 mg per day
- L-Theanine: 100-400 mg per day
- BCAA: 5-20 grams per day, depending on activity level
- L-Lysine: 1,000-3,000 mg per day
It is advisable to consult with a healthcare professional before starting any supplementation.

Oliver, 50~59 year old female. Ask Date: 2021/10/31

Dr. Hou Fangmin reply Pharmacology


Hello, Ms.
Oliver:
1.
L-Glutamine should not be used by individuals taking antiepileptic medications, as glutamine can affect the brain's chemical balance, thereby influencing the efficacy of the medications.
The medications include: phenobarbital, primidone, valproic acid, gabapentin, carbamazepine, and phenytoin.
It should not be used in conjunction with lactulose (a medication for treating constipation and improving hepatic encephalopathy), as it may affect the drug's efficacy.
The recommended dosage is 0.25 to 0.5 grams per kilogram of body weight, divided into three doses daily.
2.
L-Arginine: The WHO recommends a daily requirement of 117 mg of arginine per kilogram of body weight.
For adults weighing between 45-70 kg, the daily requirement is approximately 5-8 grams.
However, due to dietary habits and nutritional imbalances, the suggested effective dosage is between 2500 mg to 5000 mg, or 250 mg per kilogram of body weight per day.
3.
L-Phenylalanine: The recommended daily requirement for phenylalanine is also 117 mg per kilogram of body weight, which translates to approximately 5-8 grams for adults weighing 45-70 kg.
Aminoven is a parenteral nutrition supplement that contains L-phenylalanine, with 5.5 grams in 1000 ml.
The renal formula Renal-Forte, which is used for individuals with impaired kidney function, also contains L-phenylalanine.
4.
L-Theanine: The required dosage should reach 200-400 mg.
5.
Branched-Chain Amino Acids (BCAAs): A daily intake of 5-10 grams is recommended, especially before exercise.
6.
L-Lysine: For patients with herpes simplex virus (HSV) infections, such as cold sores, it is recommended to take 1000 mg three times daily for six months.
Individuals aged 13 and older require approximately 12 mg of lysine per kilogram of body weight.
For adults, the daily requirement is about 700 to 900 mg.
Among these six amino acids, some are dietary supplements, but L-phenylalanine in parenteral nutrition is administered via injection, as is Renal-Forte for those with impaired kidney function.
Most amino acids can be obtained from food, which is the best source unless there are specific treatment needs.
I hope this answers your questions clearly.
Wishing you peace, joy, and good health!

Reply Date: 2021/10/31

More Info


When it comes to the classification of supplements such as L-Glutamine, L-Arginine, L-Phenylalanine, L-Theanine, BCAAs (Branched-Chain Amino Acids), and L-Lysine, they are generally categorized as dietary supplements rather than drugs. This distinction is important because dietary supplements are intended to supplement the diet and are not meant to treat, diagnose, prevent, or cure diseases, which is the role of pharmaceuticals.


Classification of Supplements
1. L-Glutamine: This is an amino acid that plays a crucial role in protein synthesis and is often used to support muscle recovery and gut health. It is classified as a dietary supplement.

2. L-Arginine: Another amino acid, L-Arginine is known for its role in nitric oxide production, which can help improve blood flow and cardiovascular health. It is also considered a dietary supplement.

3. L-Phenylalanine: This essential amino acid is a precursor to neurotransmitters such as dopamine and norepinephrine. It is classified as a dietary supplement.

4. L-Theanine: Found primarily in tea leaves, L-Theanine is known for its calming effects and is often used to reduce stress and anxiety. It is classified as a dietary supplement.

5. BCAAs: These are a group of three essential amino acids—leucine, isoleucine, and valine—that are particularly important for muscle growth and recovery. They are classified as dietary supplements.

6. L-Lysine: This essential amino acid is important for protein synthesis and is often used to support immune function and collagen production. It is classified as a dietary supplement.


Daily Dosage Recommendations
The recommended daily dosages for these supplements can vary based on individual health needs, activity levels, and specific goals. However, here are some general guidelines:
1. L-Glutamine: Commonly recommended dosages range from 5 to 10 grams per day, especially for athletes or those recovering from surgery or illness.

2. L-Arginine: Typical dosages range from 2 to 6 grams per day, often divided into multiple doses. It is advisable to consult a healthcare provider for personalized recommendations.

3. L-Phenylalanine: Recommended dosages can vary, but a common range is 500 mg to 2,000 mg per day. Individuals with certain medical conditions (like phenylketonuria) should avoid this amino acid.

4. L-Theanine: A typical dosage is around 100 to 400 mg per day, often taken in divided doses. It is generally considered safe and well-tolerated.

5. BCAAs: A common dosage is 5 to 20 grams per day, particularly around workout times for muscle recovery.

6. L-Lysine: Recommended dosages typically range from 1,000 mg to 3,000 mg per day, especially for those looking to support immune health or manage cold sores.


Important Considerations
While dietary supplements can provide benefits, it is crucial to approach their use with caution. Here are some considerations:
- Consult Healthcare Providers: Before starting any supplement regimen, especially if you have underlying health conditions or are taking medications, consult with a healthcare provider or a registered dietitian. They can provide personalized advice based on your health status and dietary needs.

- Quality Matters: Not all supplements are created equal. Look for products that have been tested for quality and purity by third-party organizations. This ensures that what is on the label is actually in the product.

- Dietary Sources: Whenever possible, aim to obtain nutrients from whole foods rather than supplements. A balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can often meet your nutritional needs without the need for additional supplementation.

- Monitor for Side Effects: Be aware of any potential side effects or interactions with other medications. If you experience any adverse effects, discontinue use and consult a healthcare provider.

In summary, the supplements you mentioned are classified as dietary supplements rather than drugs, and their daily dosages can vary based on individual needs. Always prioritize a balanced diet and consult with healthcare professionals for tailored advice.

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