Concerns About Excess Growth Hormone in a Rapidly Growing Child - Internal Medicine

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Suspected excessive secretion of growth hormone?


Hello, my child is 7 years old and is almost 150 cm tall.
We have seen a pediatric endocrinologist twice, and they said there is no precocious puberty, but her bone age is advanced by 1 to 2 years.
We did a blood test once, and the results were normal.
It was suggested that this might be due to genetic factors (parents' heights are 180 cm and 167 cm).
However, her siblings are also tall but not as extreme as she is.
I am very concerned about the possibility of excess growth hormone.

1.
What could be the possible reasons for this?
2.
Should we consult a general metabolic specialist or continue seeing a pediatric endocrinologist? Thank you for your response.

Miss Su, 40~49 year old female. Ask Date: 2021/12/01

Dr. Li Jian reply Internal Medicine


Since your child is only seven years old, it is recommended that you consult a pediatric endocrinologist.
Thank you.

Reply Date: 2021/12/01

More Info


When it comes to concerns about excessive growth hormone in a rapidly growing child, there are several factors to consider. Your child's height of nearly 150 cm at the age of 7 is indeed above average, especially when compared to peers. However, it's important to understand that growth patterns in children can vary significantly due to a variety of factors, including genetics, nutrition, and overall health.

1. Possible Causes of Rapid Growth:
The primary reason for your child's rapid growth could be genetic. If both parents are tall (180 cm and 167 cm), it is reasonable to expect that their children may also inherit a tendency towards greater height. Additionally, children can experience growth spurts at different times, and some may grow faster than others due to individual variations in growth hormone levels, nutritional intake, and physical activity.
Other potential causes of rapid growth could include conditions such as precocious puberty, where secondary sexual characteristics develop earlier than normal, or other endocrine disorders. However, since you mentioned that your child has been evaluated by pediatric endocrinologists and no signs of precocious puberty have been found, this is less likely.

2. Next Steps in Evaluation:
Given that your child has already been assessed by pediatric endocrinologists and the results were normal, it may be beneficial to continue monitoring her growth with specialists in pediatric endocrinology. These specialists can provide a more comprehensive evaluation of growth patterns, including bone age assessments through X-rays, which can help determine if the growth is appropriate for her chronological age.

If you have concerns about metabolic issues or other underlying conditions, a consultation with a pediatric metabolic specialist could also be warranted. However, since your child's growth has been attributed to genetic factors and no immediate concerns have been raised by the endocrinologists, continuing with pediatric endocrinology seems to be the most appropriate course of action.

3. Monitoring Growth:
Regular monitoring of your child's growth is essential. Keep track of her height and weight, and compare these measurements to growth charts that are appropriate for her age and sex. If her growth rate significantly exceeds the expected range for her age group, or if she shows signs of other symptoms (such as changes in appetite, energy levels, or development of secondary sexual characteristics), it would be prudent to revisit the endocrinologist for further evaluation.

4. Understanding Growth Hormone:
Growth hormone (GH) is crucial for normal growth and development in children. It stimulates growth in almost all tissues of the body, including bone and muscle. However, excessive levels of growth hormone can lead to conditions such as gigantism in children, which is characterized by abnormal growth and height. This condition is typically caused by a pituitary adenoma (a benign tumor of the pituitary gland) that secretes excess growth hormone.
In your child's case, since the blood tests have shown normal levels of growth hormone, it is less likely that she is experiencing an overproduction of this hormone. However, if there are ongoing concerns, further testing, including MRI scans of the pituitary gland, may be warranted to rule out any abnormalities.

In summary, while your child's height is above average for her age, it is essential to consider genetic factors and continue monitoring her growth with pediatric specialists. Regular check-ups and open communication with healthcare providers will help ensure that any potential issues are addressed promptly. If you have any further concerns or if her growth pattern changes, do not hesitate to seek further evaluation.

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