Persistent Arm Pain After Injection: What You Need to Know - Internal Medicine

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It has been a long time since the injection, but it still hurts?


I received an anti-inflammatory injection in my left arm, and it has been over two months since then.
I still experience some pain, although it's not severe, and there are no visible abnormalities.
However, I occasionally feel discomfort.
I would appreciate your assistance, thank you.

Janie, 40~49 year old female. Ask Date: 2021/12/02

Dr. Lin Wufu reply Internal Medicine


Hello: It's difficult to determine the exact issue, but I recommend that you first schedule an appointment with the Rheumatology and Immunology Department at our hospital.
The physicians there can perform a soft tissue ultrasound in the clinic to check for any issues such as abscesses or fluid accumulation in your left arm.

Reply Date: 2021/12/02

More Info


Persistent arm pain following an injection can be a concerning issue, especially when it lasts for an extended period, such as two months or more. While it is not uncommon to experience some discomfort after receiving an injection, especially in the muscle, persistent pain that does not improve over time warrants further investigation.

Firstly, it is essential to understand that injections, particularly intramuscular ones, can lead to localized inflammation or irritation at the injection site. This inflammation can result from the body's immune response to the injected substance, whether it be a medication, vaccine, or other therapeutic agents. Typically, this localized pain should subside within a few days to a couple of weeks. If the pain persists beyond this timeframe, it may indicate an underlying issue that needs to be addressed.

There are several potential reasons for ongoing pain in the arm after an injection:
1. Injection Site Reaction: Some individuals may experience a prolonged inflammatory response at the injection site, leading to persistent pain. This can occur due to the body's reaction to the injected material or due to the technique used during the injection.

2. Nerve Irritation or Injury: If the injection inadvertently affected a nearby nerve, it could lead to ongoing pain or discomfort. Symptoms may include sharp, shooting pain, tingling, or numbness in the arm.

3. Muscle Strain or Injury: If there was any strain or injury to the muscle during the injection process, it could result in lingering pain. This is particularly relevant if the injection was administered in a manner that caused the muscle to contract or if the patient moved during the procedure.

4. Infection: Although rare, an infection at the injection site can lead to persistent pain. Signs of infection may include redness, swelling, warmth, or discharge from the site. However, you mentioned that there are no visible signs of infection, which is reassuring.

5. Underlying Conditions: Sometimes, the pain may not be directly related to the injection but could be exacerbated by pre-existing conditions such as tendinitis, bursitis, or other musculoskeletal issues.

Given that your pain has persisted for over two months without significant improvement, it is advisable to seek further medical evaluation. A healthcare provider may perform a physical examination and possibly recommend imaging studies, such as an ultrasound or MRI, to assess the soft tissues, muscles, and nerves in the area. This can help identify any underlying issues that may be contributing to your discomfort.

In the meantime, there are several self-care strategies you can employ to help manage the pain:
- Rest: Avoid activities that exacerbate the pain and allow the arm to rest.

- Ice Therapy: Applying ice to the affected area for 15-20 minutes several times a day can help reduce inflammation and numb the pain.

- Heat Therapy: After the initial inflammation has subsided, applying heat may help relax the muscles and improve blood flow.

- Over-the-Counter Pain Relief: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can help alleviate pain and reduce inflammation.

- Gentle Stretching and Strengthening Exercises: Once the acute pain subsides, gentle stretching and strengthening exercises may help restore function and reduce discomfort.

If the pain continues or worsens, or if you develop any new symptoms, it is crucial to consult a healthcare professional for a thorough evaluation and appropriate management. They can provide a tailored treatment plan based on the underlying cause of your persistent pain.

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