Oral A-Retinoids: Are Blisters on the Chin Normal?

Oral isotretinoin causing blisters on the chin?

Due to having rosacea, my doctor recommended taking isotretinoin (Roaccutane) three times a week.
After just one week of treatment, I noticed a blister forming on my lower right chin.
It's not a typical acne lesion; it's a raised area filled with fluid.
I would like to know if this is a normal side effect or if I should stop the medication and seek medical attention.

Song, 20~29 year old female. Ask Date: 2022/03/13

Dr. Wu Yuxin reply Dermatology

It is rare to hear about this adverse reaction from taking vitamin A acid.
You can stop the medication and discuss it with your dermatologist.

Reply Date: 2022/03/13

More Info

When considering the use of oral A-retinoids, such as isotretinoin (commonly known by the brand name Roaccutane), it is essential to understand both the potential benefits and side effects associated with this medication. Isotretinoin is primarily used to treat severe acne, including nodular acne and acne that has not responded to other treatments. It works by reducing the size and activity of sebaceous (oil) glands, thereby decreasing oil production, preventing clogged pores, and exerting anti-inflammatory effects.

In your case, the appearance of blisters on the chin after one week of treatment is concerning and warrants careful consideration. Blisters, especially those filled with fluid, are not a typical side effect of isotretinoin. Common side effects of isotretinoin include dry skin, chapped lips, dry eyes, and nosebleeds due to mucous membrane dryness. However, the development of blisters could indicate an adverse reaction or an allergic response to the medication, or it may be related to another underlying skin condition.

It is crucial to differentiate between the types of lesions you are experiencing. If the blisters are painful, itchy, or spreading, it may suggest a more serious reaction that requires immediate medical attention. Additionally, if you have a history of skin conditions such as rosacea, the introduction of isotretinoin could potentially exacerbate certain symptoms, leading to unusual skin reactions.

Given the potential for serious side effects associated with isotretinoin, including the risk of severe skin reactions, it is advisable to consult your healthcare provider as soon as possible. They may recommend discontinuing the medication temporarily to assess the situation further. Your doctor may also consider alternative treatments or adjust your dosage based on your response to the medication.

In summary, while isotretinoin can be an effective treatment for severe acne, the development of blisters on your chin is not a typical side effect and should be evaluated by a healthcare professional. It is always better to err on the side of caution when it comes to new or worsening symptoms while on medication. Your doctor will be able to provide the best guidance based on a thorough examination and your medical history.

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