Managing Facial Redness and Irritation from Oral A-Retinoids - Dermatology

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Oral isotretinoin causing facial redness?


I have been taking oral isotretinoin for about a week now, and my face is quite red, to the point where everyone notices it.
They say I have a natural blush, and it's very obvious.
How should I manage this redness? Is this a normal reaction to taking isotretinoin? Additionally, I am also using ACZO ointment, and after applying it, my face itches incredibly.
There have been several times when I wanted to wash it off with water.
Can I use a moisturizer or something else to alleviate these symptoms? Thank you, doctor.

Zhou Zhou, 10~19 year old female. Ask Date: 2023/07/22

Dr. Li Yufen reply Dermatology


Hello: For a detailed introduction to oral retinoic acid, you can refer to the article from Med's Good Friend at https://www.medpartner.club/topical-retinoid-acid-introduction/.
If applying ACZO ointment causes significant itching, it is recommended to discontinue use and return to the dermatologist for an adjustment of topical medications and to evaluate the condition of facial redness.
Thank you!

Reply Date: 2023/07/22

More Info


Managing facial redness and irritation while on oral A-retinoids can be a challenging experience, especially in the initial weeks of treatment. A-retinoids, such as isotretinoin, are commonly prescribed for severe acne and other skin conditions due to their effectiveness in reducing oil production, preventing clogged pores, and promoting skin cell turnover. However, they can also lead to various side effects, including dryness, irritation, and redness, particularly during the first few weeks of therapy.

Facial redness is indeed a common reaction when starting oral A-retinoids. This redness can be exacerbated by the skin's increased sensitivity as it adjusts to the medication. The fact that you are experiencing significant redness, which is noticeable to others, suggests that your skin may be reacting strongly to the treatment. It is essential to differentiate between normal side effects and an allergic reaction or irritation from other products you may be using, such as the ACZO ointment.

Here are some strategies to manage the redness and irritation:
1. Moisturization: Keeping your skin well-hydrated is crucial when using A-retinoids. Look for a gentle, non-comedogenic moisturizer that is free from fragrances and irritants. Apply it liberally after cleansing your face and before applying any other products. This can help create a barrier and reduce irritation.

2. Gentle Cleansing: Use a mild, non-foaming cleanser that does not strip your skin of its natural oils. Avoid exfoliating scrubs or harsh cleansers, as these can worsen irritation.

3. Avoid Irritants: Be cautious with other topical products you are using, including the ACZO ointment. If you experience itching or discomfort after applying it, consider discontinuing its use and consult your dermatologist. Sometimes, combining multiple treatments can lead to increased irritation.

4. Sun Protection: A-retinoids can make your skin more sensitive to sunlight. Use a broad-spectrum sunscreen with an SPF of at least 30 daily, even on cloudy days. This will help protect your skin from UV damage and prevent further irritation.

5. Gradual Introduction: If the redness is severe, you might consider discussing with your dermatologist the possibility of reducing the frequency of your A-retinoid application. Some patients find that starting with a lower dose or applying the medication every other day can help their skin adjust better.

6. Hydrocortisone Cream: In some cases, a mild over-the-counter hydrocortisone cream may help reduce inflammation and redness. However, this should be used sparingly and not as a long-term solution. Always consult your dermatologist before starting any new treatment.

7. Consult Your Dermatologist: If the redness and irritation persist or worsen, it is essential to reach out to your dermatologist. They can assess your skin's condition and may recommend alternative treatments or adjustments to your current regimen.

In summary, while some redness and irritation can be expected when starting oral A-retinoids, it is crucial to manage these symptoms effectively to ensure the best possible outcome from your treatment. By implementing a gentle skincare routine, moisturizing adequately, and consulting with your dermatologist, you can help alleviate these side effects and continue your treatment safely. Remember, patience is key, as your skin may take time to adjust to the medication.

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