Can You Have Sex After Taking the First Dose of RU486? - Obstetrics and Gynecology

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Can I have sexual intercourse after taking the first dose of RU486?


Hello, I took the first dose of RU486 on March 19 at 3:00 PM, and had intercourse on March 20 at 11:00 AM.
Will this affect the efficacy of the medication? Thank you!

M, 30~39 year old female. Ask Date: 2022/03/20

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2022/03/20

More Info


RU486, also known as mifepristone, is primarily used for medical abortion. It works by blocking the hormone progesterone, which is necessary for the continuation of pregnancy. When considering the timing of sexual intercourse after taking RU486, it is essential to understand how the medication functions and its implications on fertility and sexual activity.

When you take the first dose of RU486, it does not immediately terminate a pregnancy. The process typically involves taking a second medication, usually misoprostol, 24 to 48 hours later, which induces contractions and helps expel the pregnancy tissue. Therefore, if you engage in sexual intercourse shortly after taking the first dose of RU486, it is unlikely to affect the medication's efficacy in terminating an existing pregnancy. However, it is important to note that while the first dose may not lead to immediate effects, the overall process of medical abortion takes time, and the body may still be in a state of pregnancy until the second medication is taken and the process is completed.

In your specific case, having sexual intercourse approximately 20 hours after taking the first dose of RU486 is generally considered safe in terms of not affecting the drug's effectiveness. However, it is crucial to understand that if the abortion process has not been completed, there remains a risk of pregnancy if no other contraceptive methods are used. Once the abortion is confirmed complete, the risk of becoming pregnant again is present if you do not use contraception during subsequent sexual activities.

Additionally, it is important to consider the emotional and physical aspects of engaging in sexual activity after taking RU486. Some individuals may experience cramping, bleeding, or emotional distress during the abortion process, which could affect their desire or ability to engage in sexual activity. It is advisable to communicate openly with your partner about comfort levels and any concerns regarding sexual activity during this time.

In terms of future fertility, RU486 does not have a long-term impact on a person's ability to conceive. Once the abortion process is complete, fertility typically returns to normal, and individuals can become pregnant again if they do not use contraception. Therefore, if you are concerned about future pregnancies, it is wise to discuss contraceptive options with your healthcare provider.

In summary, having sex after taking the first dose of RU486 does not affect the medication's efficacy in terminating a pregnancy. However, it is essential to be aware of the ongoing risk of pregnancy until the abortion process is fully completed. If you have further questions or concerns about your sexual health or contraceptive options, it is always best to consult with a healthcare professional for personalized advice and guidance.

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