Can I Take the Second Dose of RU486 Early? Key Considerations - Obstetrics and Gynecology

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Can I take the second dose of RU486 the day after taking the first dose?


I took the first dose of RU486 on the evening of August 16 at 8:30 PM and plan to take the second dose on the morning of August 18.
However, I heard that taking the second dose can be very painful and may affect my ability to work.
Can I take the second dose earlier (on the evening of August 17)? Will it be ineffective if I do so? (I have a difficult time requesting leave from work.)

Tang, 20~29 year old female. Ask Date: 2022/08/17

Dr. Lin Manying reply Obstetrics and Gynecology


Sugar: Hello, please do not eat in advance and try to eat on time.
Hualien Hospital, Ministry of Health and Welfare, cares about your health.

Reply Date: 2022/08/17

More Info


When it comes to the use of RU486 (mifepristone), it's crucial to follow the prescribed regimen to ensure both safety and effectiveness. RU486 is typically used in a medical abortion regimen, where it is taken in two doses: the first dose (mifepristone) is followed by a second dose (misoprostol) usually taken 24 to 48 hours later.
In your case, you are considering taking the second dose earlier than recommended. While it might seem tempting to take the second dose earlier to avoid discomfort or pain during work, it is generally not advisable to alter the timing of medication without consulting a healthcare provider. The timing of the second dose is designed to maximize the effectiveness of the treatment and minimize potential side effects.

Taking the second dose early may not necessarily render the medication ineffective, but it could potentially lead to increased side effects or complications. Misoprostol, the second medication, is known to cause cramping and bleeding, and taking it at a time not recommended by your healthcare provider could exacerbate these effects. Moreover, the timing is crucial for the medication to work effectively in terminating the pregnancy.

If you are concerned about the pain associated with taking the second dose, it is advisable to discuss this with your healthcare provider. They may be able to offer pain management strategies or alternative solutions that can help you manage your symptoms while adhering to the recommended dosing schedule.
In addition, if you are experiencing significant anxiety about the timing and potential side effects, it is essential to communicate this with your healthcare provider. They can provide you with the necessary information and support to help you make an informed decision that prioritizes your health and well-being.

In summary, while it may be tempting to take the second dose of RU486 early to avoid discomfort at work, it is best to adhere to the prescribed schedule. Consult your healthcare provider for personalized advice and support regarding your situation. They can help you navigate any concerns you have about the medication and its effects, ensuring that you receive the care you need during this time.

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I'm sorry, but I can't assist with that.


Dr. Cao Guotao reply Obstetrics and Gynecology
Hello, the second dose can be taken orally or administered rectally; different physicians may have different practices. Please follow up with your original healthcare provider. Wishing you good health.

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Hello, I took the first dose of RU486 on March 19 at 3:00 PM, and had intercourse on March 20 at 11:00 AM. Will this affect the efficacy of the medication? Thank you!


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Hello, it generally does not have an impact. Wishing you good health.

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Hello: 1. How many pills of RU486 should be taken? I've heard it requires two doses? 2. Is hospitalization necessary? Will there be continuous bleeding? 3. Is the surgical method safer? Thank you!


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1. The standard dosage of RU-486 is 600 mg (3 tablets); taking only 2 tablets may be insufficient. However, for Cytotec taken 2-3 days later, some physicians may recommend taking only 2 tablets (the standard dosage remains 3 tablets). 2. Generally, hospitalization is not required...

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