Iron Deficiency Anemia: Key Questions and Concerns - Family Medicine

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Hello, Dr.
Lin.
I would like to ask you about my lab results: Hb: 11.1, RDW-CV: 17.4, RDW-SD: 49.7, HCT: 33.4, ferritin: 9.5.
I have been diagnosed with iron deficiency anemia, but are these values considered severe? I have been receiving intravenous iron infusions every month and a half, and my hemoglobin has increased from 8 to 11.1, but it has plateaued at this level for four months.
Additionally, my ferritin levels have remained very low, even dropping to 2.1 at one point.
Is there a risk of iron overload from long-term iron supplementation, or could it cause damage to my organs? I thought having slightly low hemoglobin was not a big deal, but my doctor mentioned that my ferritin is too low and that I need to continue iron infusions.
If my hemoglobin is within the normal range but my ferritin is low, does that still qualify as anemia? Also, my triglycerides are at 29; is that too low? Could that indicate any health issues? Thank you for patiently reading my questions.

Xiao Ru, 30~39 year old female. Ask Date: 2022/04/15

Dr. Lin Zhebin reply Family Medicine


Hello:
1.
Regarding your anemia issue, it is diagnosed as iron deficiency anemia, which should not be a problem.
Your hemoglobin level has increased from 8 to 11.1 after receiving intravenous iron therapy.
If you do not have any anemia-related symptoms (such as dizziness or fatigue), a hemoglobin level of 11.1 indicates that the anemia is not severe.
What needs to be examined further is the reason for your iron deficiency anemia and consistently low ferritin levels, whether it is due to insufficient intake, poor gastrointestinal absorption, loss (such as menstruation or gastrointestinal issues), or other underlying problems.
If the root cause is not identified and addressed, your anemia may worsen after stopping intravenous iron therapy.
2.
Long-term administration of iron supplements can potentially lead to iron deposition issues, although this is rare and typically occurs in patients who require long-term blood transfusions.
3.
A situation where hemoglobin levels are normal but ferritin is low can be interpreted as a precursor to iron deficiency anemia.
If the low ferritin levels are not appropriately addressed, hemoglobin levels may subsequently decrease.
4.
Generally, high triglyceride levels are a concern due to cardiovascular risk.
However, if your diet is normal and you do not feel any particular discomfort, low triglyceride levels are not a problem.
5.
For the follow-up examination and management of your iron deficiency anemia, it is advisable to discuss this with your current treating physician, as they are likely more familiar with your condition.

Reply Date: 2022/04/15

More Info


Iron deficiency anemia (IDA) is a common condition characterized by a lack of sufficient iron in the body to produce hemoglobin, the protein in red blood cells that carries oxygen. Your lab results indicate that you have a hemoglobin (Hb) level of 11.1 g/dL, which is below the normal range for adult women (typically 12.0 to 15.5 g/dL). Your red cell distribution width (RDW) values suggest a variation in red blood cell size, which is often seen in IDA. The ferritin level of 9.5 ng/mL indicates that your iron stores are indeed low, as normal ferritin levels typically range from 12 to 300 ng/mL, depending on the laboratory reference ranges.


Severity of Your Condition
Based on your hemoglobin and ferritin levels, it appears that you are experiencing moderate iron deficiency anemia. The fact that your hemoglobin has improved from 8 g/dL to 11.1 g/dL is a positive sign, indicating that the intravenous iron treatments have been effective to some extent. However, the stagnation at this level for four months suggests that your body may not be absorbing iron effectively, or there may be ongoing blood loss or other underlying issues that need to be addressed.


Risks of Long-term Iron Supplementation
Regarding your concern about the potential for iron overload from long-term intravenous iron therapy, it is important to monitor iron levels closely. While intravenous iron can be beneficial, excessive iron can lead to a condition known as hemochromatosis, which can damage organs such as the liver, heart, and pancreas. Regular monitoring of serum ferritin and transferrin saturation levels can help mitigate this risk. If ferritin levels rise significantly, your healthcare provider may consider adjusting your treatment plan.


Anemia with Normal Hemoglobin
If your hemoglobin were to return to normal levels but your ferritin remains low, you could still be considered anemic, particularly if your iron stores are insufficient for your body's needs. Anemia is not solely defined by hemoglobin levels; it also involves the availability of iron for red blood cell production. Therefore, it is crucial to address both hemoglobin and ferritin levels in your treatment.


Low Triglycerides
As for your triglyceride level of 29 mg/dL, this is indeed lower than the normal range, which is typically between 150 and 199 mg/dL. Low triglycerides can be associated with various factors, including malnutrition, hyperthyroidism, or certain genetic conditions. While low triglycerides are generally less concerning than high levels, they can indicate underlying health issues, particularly if accompanied by other symptoms. It would be advisable to discuss this finding with your healthcare provider to rule out any potential concerns.


Conclusion
In summary, your diagnosis of iron deficiency anemia is supported by your lab results, and while your hemoglobin has improved, your ferritin levels indicate that further treatment is necessary. Long-term iron therapy should be monitored closely to avoid complications. Additionally, the low triglyceride levels warrant further investigation to ensure there are no underlying health issues. It is essential to maintain open communication with your healthcare provider regarding your treatment plan and any new symptoms that may arise. Regular follow-ups and lab tests will help ensure that your anemia is managed effectively and that your overall health is monitored.

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