Can Probiotics Disrupt Sleep? the Connection - Gastroenterology and Hepatology

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Taking probiotics may disrupt sleep?


Taking probiotics before bedtime may lead to some insomnia, causing difficulty in falling asleep and waking up multiple times during the night.
This is quite intriguing, and there is limited information available on this topic.
It is unclear why this happens, but individual responses to probiotics can vary.
Over time, your body may adjust, and the effects could improve.
Thank you!

Zzz, 10~19 year old female. Ask Date: 2022/05/11

Dr. Chen Shidian reply Gastroenterology and Hepatology


There should be no reports or studies on this phenomenon; you may stop taking it or resume taking it for comparative observation.

Reply Date: 2022/05/11

More Info


Probiotics are live microorganisms that can provide health benefits when consumed in adequate amounts. They are often associated with digestive health, but their effects on sleep are less well understood. Your experience of having difficulty falling asleep and waking up multiple times after taking probiotics is indeed intriguing and warrants a closer look.

Firstly, it's important to understand that sleep is a complex process influenced by various factors, including diet, stress levels, physical activity, and overall health. Probiotics can affect gut health, which in turn can influence sleep quality. The gut-brain axis is a term used to describe the bidirectional communication between the gastrointestinal tract and the brain. Research has shown that gut health can impact mood and anxiety levels, which are closely linked to sleep quality.

Some studies suggest that certain strains of probiotics may help improve sleep quality by reducing anxiety and stress levels. For example, Lactobacillus and Bifidobacterium strains have been shown to have potential anxiolytic effects. However, the response to probiotics can vary significantly from person to person. In some cases, probiotics may lead to gastrointestinal discomfort, bloating, or changes in bowel habits, which could indirectly affect sleep.

In your case, if you find that taking probiotics before bed is leading to sleep disturbances, it may be worth considering a few factors:
1. Timing of Probiotic Intake: The timing of when you take probiotics can influence their effects. If you are taking them right before bed, it might be beneficial to try taking them earlier in the day. This could help minimize any potential digestive discomfort that might disrupt your sleep.

2. Strain Specificity: Different strains of probiotics have different effects. If you are using a specific probiotic blend, it might be worth researching its components or consulting with a healthcare professional to see if there are strains that are known to be more beneficial for sleep.

3. Underlying Conditions: If you have underlying gastrointestinal issues or other health conditions, these could be contributing to your sleep disturbances. It may be helpful to discuss your symptoms with a healthcare provider who can evaluate your overall health and recommend appropriate interventions.

4. Sleep Hygiene Practices: In addition to considering the impact of probiotics, it's essential to maintain good sleep hygiene. This includes establishing a regular sleep schedule, creating a comfortable sleep environment, and avoiding stimulants like caffeine close to bedtime.

5. Duration of Use: Sometimes, the body needs time to adjust to new supplements. If you have recently started taking probiotics, it might take some time for your body to adapt. However, if the sleep disturbances persist, it would be wise to reassess their use.

In conclusion, while probiotics can have various health benefits, their impact on sleep can vary widely among individuals. If you continue to experience sleep disturbances after taking probiotics, it may be beneficial to consult with a healthcare professional. They can help determine if the probiotics are contributing to your sleep issues and suggest alternative approaches to improve your sleep quality. Additionally, maintaining good sleep hygiene and considering the timing and strain of probiotics can also play a significant role in your overall sleep health.

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