Vulvar Papilloma: Insights from Biopsy Reports - Obstetrics and Gynecology

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Vulvar Papillary Biopsy Report


Due to the presence of a papillomatous lesion on the vulva, the doctor was unable to make a visual diagnosis and requested a biopsy.
The report is as follows, and I would like to ask:
1.
Does this report rule out the possibility of the papillomatous lesion being a condyloma acuminatum (genital wart)? If it were indeed a condyloma, would it be clearly stated as such in the report?

2.
Is this papilloma a pseudocondyloma, or is there a possibility of a sexually transmitted infection? The doctor mentioned it is a benign "virus," but has advised me to pay out of pocket for further testing.
3.
Does this report confirm that the papilloma is associated with a "virus," or is this merely the doctor's speculation?
Thank you very much for taking the time to respond.

Pathological Diagnosis: Vulva, biopsy, squamous papilloma
Description: The specimen submitted consists of 3 tissue fragments measuring up to 0.5 x 0.2 x 0.1 cm in size, fixed in formalin.
Grossly, they are grayish and soft.

Microscopically, the section shows a papillary lesion covered by squamous epithelium with acanthosis.
Fibrovascular tissue is found in the subepithelial stroma.
There is no evidence of malignancy.

Luci, 30~39 year old female. Ask Date: 2022/06/15

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, this is the pathology report.
The descriptions may vary slightly between hospitals, so it is recommended that you consult with a pathologist.
Wishing you good health.

Reply Date: 2022/06/15

More Info


Understanding vulvar papilloma, particularly in the context of your biopsy report, involves several key aspects regarding its nature, potential for transmission, and treatment options.
Firstly, the term "squamous papilloma" refers to a benign growth that arises from squamous epithelial cells, which are the flat cells that make up the outer layer of the skin and mucous membranes. In your case, the report indicates that the lesion is a papillary structure covered by squamous epithelium with acanthosis (thickening of the skin) and fibrovascular tissue in the subepithelial stroma. Importantly, the report states that there is no evidence of malignancy, which suggests that the growth is benign.

1. Differentiation from Condyloma (Genital Warts): Your concern about whether this lesion could be condyloma (commonly known as genital warts) is valid. Condyloma is caused by certain strains of the human papillomavirus (HPV), particularly types 6 and 11, which are considered low-risk for cancer but can cause warty growths. The pathology report does not explicitly mention condyloma, which is a good sign, as it typically would if the lesion were indeed a wart. However, it is important to note that squamous papillomas can sometimes be associated with HPV, albeit typically with different strains than those causing condyloma. Therefore, while the report does not confirm condyloma, it does not entirely rule out the possibility of HPV involvement.

2. Transmission and Treatment: Squamous papillomas are generally not considered sexually transmitted. They can occur due to various factors, including irritation or chronic inflammation. Since your doctor has indicated that the lesion is benign and does not appear to be a sexually transmitted infection, treatment may not be necessary unless the growth is causing discomfort or cosmetic concerns. If the lesion is asymptomatic, many healthcare providers may recommend simply monitoring it rather than pursuing aggressive treatment.

3. Further Testing: Your doctor’s suggestion to undergo additional testing may be aimed at determining the specific type of HPV, if any, associated with your lesion. While the biopsy confirms that the lesion is benign, knowing the HPV type can provide more information regarding any potential risks for future lesions or other HPV-related conditions. It is not uncommon for healthcare providers to recommend further testing, especially if there is a history of HPV or if there are concerns about other lesions.

4. Understanding the Report: The pathology report does not confirm the presence of a "virus" per se; rather, it describes the histological features of the lesion. The term "virus" in this context is likely a reference to the potential association with HPV, but the report itself does not provide a definitive diagnosis of a viral infection. Your doctor may be considering the broader context of your health history and any previous HPV tests when discussing the potential implications of the biopsy findings.

In conclusion, while your biopsy report indicates a benign squamous papilloma, it is essential to have a thorough discussion with your healthcare provider regarding the implications of the findings, the necessity of further testing, and any potential treatment options. Regular follow-ups and monitoring are crucial in managing any skin or mucosal lesions, especially those associated with HPV. If you have further questions or concerns, do not hesitate to reach out to your healthcare provider for clarification and guidance tailored to your specific situation.

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