Fatty Liver: Normal Liver Enzymes and Your Health Status - Internal Medicine

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Continuation 173038 Fatty Liver Issues


Hello Doctor, my liver enzyme levels have returned to normal.
Does this mean that my liver has resolved the condition of fatty liver disease, or is it possible for fatty liver disease to have normal liver enzyme levels? Or is it currently just simple moderate to severe fatty liver? Over the past year, I have lost about 7% of my body weight (though I have slightly regained some weight).
I found in the literature that a weight loss of 7-10% can lead to significant improvement in fatty liver, correct? The doctor who drew my blood mentioned that if it is not hepatitis B or C (which I do not have), the likelihood of fatty liver causing fibrosis or cirrhosis is very low, and that I shouldn't worry.
Additionally, an ultrasound can be done every 2-3 years.
I would like to hear your opinion on this.
Thank you, Doctor.

Nìmíng, 20~29 year old female. Ask Date: 2022/07/29

Dr. Hong Yuanbin reply Internal Medicine


Hello, a normal liver index indicates that there is no inflammation in the liver.
Weight loss can indeed improve fatty liver.
As for whether the fatty liver has improved, it still requires follow-up with ultrasound to determine.
I agree with your physician's opinion that an ultrasound should be performed approximately every 2-3 years.
Thank you for your question.

Reply Date: 2022/07/29

More Info


Fatty liver disease, also known as hepatic steatosis, is a condition characterized by the accumulation of excess fat in liver cells. It can be classified into two main types: alcoholic fatty liver disease and non-alcoholic fatty liver disease (NAFLD). The latter is more common and is often associated with obesity, diabetes, and metabolic syndrome.
Regarding your question about liver enzyme levels, it is indeed possible for liver enzymes (such as GOT and GPT) to return to normal even if fatty liver is still present. Normal liver enzyme levels can indicate that there is no active inflammation or significant liver damage at that moment, but they do not necessarily confirm the absence of fatty liver itself. Fatty liver can exist without causing elevated liver enzymes, especially in its early stages. Therefore, while normalized liver enzymes are a positive sign, they do not definitively rule out the presence of fatty liver.

You mentioned that you have lost approximately 7% of your body weight, which is a significant achievement. Research indicates that losing 7-10% of body weight can lead to substantial improvements in liver health, including a reduction in liver fat and inflammation. This weight loss can help reverse the effects of fatty liver disease, and in many cases, it can lead to a complete resolution of the condition. However, maintaining this weight loss is crucial, as regaining weight can lead to a recurrence of fatty liver.

As for the concern about fibrosis or cirrhosis, it is true that the risk of progression to these more severe liver conditions is lower in individuals without chronic viral hepatitis (such as hepatitis B or C) and those who have made lifestyle changes, such as weight loss and improved diet. Regular monitoring through ultrasound and blood tests is advisable to track liver health over time. Your doctor’s recommendation to have ultrasounds every 2-3 years is reasonable, especially if your liver enzymes remain normal and you are maintaining a healthy lifestyle.

To further support your liver health, consider the following dietary and lifestyle adjustments:
1. Balanced Diet: Focus on a diet rich in fruits, vegetables, whole grains, and lean proteins. Avoid processed foods high in sugar and unhealthy fats. Foods like oats, nuts, and fatty fish (rich in omega-3 fatty acids) can be beneficial.

2. Regular Exercise: Aim for at least 150 minutes of moderate-intensity aerobic activity each week, combined with strength training exercises. Physical activity helps with weight management and improves insulin sensitivity.

3. Limit Alcohol: If you consume alcohol, do so in moderation. Excessive alcohol intake can exacerbate liver damage.

4. Stay Hydrated: Drink plenty of water and limit sugary beverages, which can contribute to weight gain and fatty liver.

5. Regular Check-ups: Continue to have regular check-ups with your healthcare provider to monitor your liver health and any other potential risk factors.

In summary, while normal liver enzymes are a good sign, they do not completely rule out fatty liver disease. Your weight loss efforts are commendable and can lead to significant improvements in liver health. Continue to focus on a healthy lifestyle, and maintain regular follow-ups with your healthcare provider to ensure your liver remains healthy.

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