Elevated Rheumatoid Factor: What You Need to Know - Internal Medicine

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Elevated rheumatoid factor issue?


Hello, Doctor.
Last month, at the end of July, I underwent a comprehensive health check-up and unexpectedly found that my rheumatoid factor was elevated (242 IU/ml, with a reference range of below 20 IU/ml).
All other health check items were almost normal.
I do not have any joint issues, and after researching online, I found that elevated levels can be associated with conditions such as dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and scleroderma, but I don't seem to have any of these issues.
I would like to ask you: 1.
Since the health report mentioned that a small number of normal individuals may also have elevated RF levels, and I have no symptoms, should I not be too concerned? 2.
If the immunology tests do not indicate rheumatoid arthritis or any of the aforementioned conditions causing the elevated RF, which specialty should I consult to investigate the cause of the abnormal index? 3.
Could having a cold on the day of the health check-up potentially affect the results? Thank you for your answers, Doctor!

Amy, 30~39 year old female. Ask Date: 2022/08/09

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Here are my responses:
1.
The health check report indicates that a small number of healthy individuals may also have elevated RF factors—if I have no symptoms, should I not worry too much? --> Some symptoms can be very mild and may go unnoticed.
It is advisable to consult a rheumatologist.
I believe your RF value is significantly elevated, and a physician can help rule out other causes of elevated RF, including a simple medical history inquiry and physical examination.
If necessary, further blood tests may be required.
If subsequent tests are normal, the physician will inform you about future monitoring methods.
2.
If the immunology tests do not indicate rheumatoid arthritis or any of the aforementioned conditions causing elevated RF, which specialty should I consult to investigate the abnormal index? --> It is recommended to first see a rheumatologist.
3.
Could having a cold on the day of the health check affect the results? --> It should not have an impact.

Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2022/08/09

More Info


Elevated rheumatoid factor (RF) can be a concerning finding, especially when it appears in the context of a routine health check-up. Understanding the implications of this result requires a nuanced approach, as RF can be elevated for various reasons, not all of which indicate a serious underlying condition.
1. Understanding Elevated RF: Rheumatoid factor is an antibody that can be present in the blood of individuals with rheumatoid arthritis (RA) and other autoimmune diseases. However, it is important to note that elevated RF levels can also occur in healthy individuals, particularly in older adults. In fact, studies suggest that RF can be found in approximately 5% of the general population without any autoimmune disease. Therefore, if you are asymptomatic and your RF level is elevated, it may not necessarily indicate a serious health issue.
2. Next Steps: If your RF is elevated but you do not exhibit any symptoms of autoimmune diseases (such as joint pain, swelling, or stiffness), it may be prudent to monitor the situation rather than pursue aggressive diagnostic measures immediately. However, if you are concerned or if your RF levels continue to rise, consulting with a rheumatologist would be a logical next step. They can perform a comprehensive evaluation, including a detailed medical history, physical examination, and possibly additional laboratory tests to rule out or confirm any underlying conditions.

3. Impact of Illness on RF Levels: Acute illnesses, including infections like the common cold, can indeed influence RF levels. Inflammatory responses triggered by infections can lead to transient elevations in RF. If you were experiencing symptoms of a cold on the day of your health check-up, it is possible that this could have contributed to the elevated RF result.
In summary, while an elevated RF can be a marker for autoimmune diseases, it is not definitive on its own. The absence of symptoms is a reassuring factor, and many individuals with elevated RF levels live without significant health issues. Regular monitoring and consultation with a healthcare provider, particularly a rheumatologist if necessary, can help clarify the situation.
In addition, it is essential to maintain a healthy lifestyle, including regular exercise, a balanced diet, and adequate sleep, as these factors can contribute to overall well-being and may help mitigate any potential health issues. If you notice any new symptoms or changes in your health, it is important to seek medical advice promptly.
Lastly, remember that medical knowledge is continually evolving, and staying informed through reputable sources and regular check-ups is key to managing your health effectively.

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