Do Anti-Inflammatory Medications Affect Birth Control Pill Efficacy? - Obstetrics and Gynecology

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Will taking anti-inflammatory medications affect oral contraceptives?


Hello Doctor, I recently suffered a heel strain and have been under the care of an orthopedic physician.
I have taken anti-inflammatory and pain relief medications for about three weeks, which include: 1.
"Shengda" Enteric-coated Tablets 100 mg 2.
"Hsin-Hui" Muscle Relaxant Tablets 3.
"Nankuang" Enteric-coated Tablets 4.
"Meifishu" Muscle Tablets 200 mg 5.
"Yongxin" Non-steroidal Potassium Coated Tablets 50 mg 6.
"Jianqiao" Colchicine Tablets 0.5 mg, and I have received two injections of anti-inflammatory and pain relief medication.
Since I have been taking oral contraceptives continuously for about two years, I would like to ask if these medications will affect the contraceptive efficacy of the oral contraceptives.
Thank you, Doctor!

Niming, 20~29 year old female. Ask Date: 2022/08/11

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, anti-inflammatory medications generally do not have an impact.
Wishing you good health.

Reply Date: 2022/08/11

More Info


When it comes to the interaction between anti-inflammatory medications and birth control pills, it is essential to understand how different classes of medications can affect the efficacy of hormonal contraceptives. The medications you mentioned include various non-steroidal anti-inflammatory drugs (NSAIDs) and other pain relief medications. Generally, NSAIDs like ibuprofen and naproxen do not have a significant impact on the effectiveness of birth control pills.
The primary concern with birth control pills is their interaction with certain medications that can induce liver enzymes, particularly those in the cytochrome P450 system. These enzymes can increase the metabolism of the hormones in birth control pills, potentially reducing their effectiveness. Common medications that are known to affect birth control efficacy include some antibiotics (like rifampin), anticonvulsants, and certain herbal supplements (like St. John's Wort). However, the anti-inflammatory medications you listed do not fall into these categories.

1. Anti-Inflammatory Medications: The medications you mentioned, such as "生達"炎立消膜衣錠 (an NSAID), "杏輝"弛筋定錠 (which may contain muscle relaxants), and others like "南光"撲炎喜腸溶膜衣錠, are primarily used for pain relief and inflammation. They do not typically interfere with the hormonal pathways that birth control pills utilize. Therefore, their use should not compromise the contraceptive effectiveness of your birth control pills.

2. Hormonal Contraceptives: Birth control pills work by delivering synthetic hormones (estrogen and progestin) that prevent ovulation, thicken cervical mucus, and thin the uterine lining. Since the medications you are taking do not induce liver enzymes that metabolize these hormones, they should not reduce the effectiveness of your contraceptive method.

3. Considerations for Long-term Use: While the medications you are taking are not known to affect birth control efficacy, it is always a good practice to consult with your healthcare provider about any concerns regarding medication interactions, especially if you are on long-term medication. They can provide personalized advice based on your health history and the specific medications you are taking.

4. Monitoring for Side Effects: If you experience any unusual side effects or changes in your menstrual cycle while taking these medications, it is advisable to discuss these with your healthcare provider. They can help determine if these changes are related to the medications or other factors.

5. Consulting with Healthcare Providers: If you have any doubts or concerns about the medications you are taking and their potential interactions with your birth control pills, it is best to consult with both your prescribing physician and your gynecologist. They can provide you with the most accurate and relevant information based on your specific situation.

In summary, the anti-inflammatory medications you are currently taking should not affect the efficacy of your birth control pills. However, always keep an open line of communication with your healthcare providers regarding any medications you are taking and any concerns you may have about their interactions. This will ensure that you receive the best possible care tailored to your needs.

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