Abnormal Pap Smears and HPV Testing in Women's Health - Obstetrics and Gynecology

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Pap smear test + HPV testing


Hello, doctor.
I previously had a Pap smear that reported "abnormal" cells with mild dysplasia and the presence of koilocytic cells (CIN 1).
I subsequently underwent another Pap smear and an HPV cervical biopsy, which again reported CIN 1, but all HPV tests were negative.
I would like to ask:
1.
Does this indicate that I have been infected in the past, but my immune system has cleared the virus? If I continue to have abnormal results but all HPV tests are negative, what could be the reason?
2.
I have normal Pap smears and HPV tests every year.
My boyfriend this year has had unprotected sex with previous partners.
Given this situation, if we have unprotected intercourse, what is the likelihood that I could be infected by him?
3.
Are HPV carriers typically male?
4.
Is it more difficult for men to be tested for HPV, and is there a higher chance of insufficient viral load in their tests?
5.
If a man is infected with HPV, will he only know about it after the 10-year latency period when symptoms appear?
6.
If I have plans to become pregnant but am concerned about HPV infection, what should I do?

Ms. Chen, 30~39 year old female. Ask Date: 2022/08/15

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, being HPV negative does not mean that cervical lesions cannot occur.
You should consider undergoing a cervical conization procedure for treatment.
The best way to prevent HPV is to use condoms, as it is primarily transmitted through sexual contact.
It's important to stay vigilant.
Wishing you good health.

Reply Date: 2022/08/15

More Info


Understanding abnormal Pap smears and HPV testing is crucial for women's health, especially given the implications for cervical cancer and overall reproductive health. Your situation involves several important aspects that need to be addressed.

1. HPV Infection and Immune Response: The presence of abnormal cells (CIN 1) along with the detection of koilocytic (hollow) cells in your Pap smear suggests that there may have been an HPV infection at some point. However, the fact that your HPV test results are negative indicates that your immune system has likely cleared the virus. The human body can often eliminate HPV on its own, particularly in younger individuals, which is why many HPV infections do not lead to long-term health issues. If your Pap smear continues to show abnormal results despite negative HPV tests, it could be due to other factors, such as inflammation or other non-viral causes.

2. Risk of Transmission: Engaging in unprotected sexual intercourse with a partner who has had multiple sexual partners increases the risk of HPV transmission. If your boyfriend has not been tested for HPV and has had unprotected sex with previous partners, there is a possibility that he could carry the virus. However, not all individuals with HPV will show symptoms or have detectable virus levels at all times. Therefore, while the risk is present, it is not guaranteed that you will contract HPV from him.

3. HPV Carriers: HPV can affect both men and women, but it is often underdiagnosed in men because there is no routine screening test equivalent to the Pap smear for women. Many men may carry the virus without knowing it, as they often do not exhibit symptoms. This makes it challenging to identify carriers and manage the risk of transmission effectively.

4. Testing in Men: Testing for HPV in men is indeed more complicated. The most common method for testing involves taking a sample from the genital area, but the sensitivity of these tests can vary, and there may be instances of insufficient viral load for detection. As a result, many men may not be diagnosed even if they are carriers.

5. Latency and Symptoms: HPV can remain dormant in the body for many years without causing any symptoms. It is possible for an individual to be infected and not know it for a decade or longer. Regular check-ups and open communication with sexual partners about health status are essential for managing risks.

6. Pregnancy Considerations: If you are planning to conceive and are concerned about HPV, it is advisable to consult with your healthcare provider. They can provide guidance on how to manage your health and any potential risks associated with HPV during pregnancy. Generally, most women with HPV can have healthy pregnancies, but it is essential to monitor any cervical changes closely.

In summary, while your current HPV status is negative, the history of abnormal Pap smears indicates the need for continued monitoring. It is essential to maintain regular screenings and communicate openly with your partner about sexual health. If you have concerns about HPV transmission or your reproductive health, consider discussing these with a healthcare provider who can offer personalized advice and support.

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