Can You Safely Combine Oral A Acid with Multivitamins? - Dermatology

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Oral retinoids and multivitamins issues?


(1) Currently, I am taking oral isotretinoin 20mg every 3 to 4 days.
(2) Before starting isotretinoin, I was taking a multivitamin (Centrum for Women), which contains 600mcg of vitamin A per tablet.
(3) Since I am concerned about the multivitamin going to waste, I would like to inquire if it is possible to take one tablet of Centrum once a week, or even once every two weeks, on different days from when I take isotretinoin.
Thank you very much!

Jiao, 30~39 year old female. Ask Date: 2022/09/24

Dr. Wu Yuxin reply Dermatology


Vitamin A acid and vitamin A are not the same.

Reply Date: 2022/09/24

More Info


Combining medications and supplements can be a complex issue, especially when it comes to vitamin A and oral retinoids like oral A acid (often referred to as isotretinoin). Your concern about safely combining these substances is valid, and it’s essential to approach this matter with caution.

First, let's clarify what oral A acid (isotretinoin) is. It is a powerful medication primarily used to treat severe acne. It works by reducing oil production in the skin, preventing clogged pores, and has anti-inflammatory properties. However, isotretinoin is a derivative of vitamin A, and it can lead to hypervitaminosis A if taken in excess. Hypervitaminosis A can cause a range of symptoms, including nausea, headaches, dizziness, and in severe cases, liver damage.

Now, regarding your multivitamin, which contains 600 mcg of vitamin A per capsule, it is crucial to consider the total intake of vitamin A from all sources. The recommended dietary allowance (RDA) for vitamin A varies by age and gender, but for adult women, it is typically around 700 mcg of retinol activity equivalents (RAE) per day. Since isotretinoin is already a potent form of vitamin A, adding additional vitamin A through supplements can increase the risk of toxicity.

Given that you are taking isotretinoin at a dosage of 20 mg every 3 to 4 days, it is advisable to be cautious with your vitamin A intake. While the body can tolerate some excess vitamin A, chronic high levels can lead to toxicity. Therefore, taking a multivitamin that contains vitamin A while on isotretinoin may not be the best choice unless monitored closely by a healthcare professional.

In your case, if you are concerned about wasting your multivitamin, it might be better to consider the following options:
1. Consult Your Healthcare Provider: Before making any changes to your supplement regimen, it is essential to discuss this with your prescribing physician or a registered dietitian. They can provide personalized advice based on your health status and dietary intake.

2. Adjust the Frequency of Multivitamin Intake: If your healthcare provider agrees, you might consider taking the multivitamin less frequently, such as once a week or every two weeks, as you suggested. However, ensure that this does not lead to exceeding the safe limits of vitamin A.

3. Monitor for Symptoms: If you decide to continue taking the multivitamin, be vigilant for any symptoms of vitamin A toxicity, such as headaches, dizziness, or gastrointestinal issues. If you experience any of these symptoms, it would be wise to discontinue the multivitamin and consult your healthcare provider.

4. Focus on a Balanced Diet: Instead of relying solely on supplements, aim to obtain your vitamins and minerals from a well-balanced diet rich in fruits, vegetables, whole grains, and lean proteins. This approach can help you meet your nutritional needs without the risk of excessive vitamin A intake.

In conclusion, while it may be possible to combine isotretinoin with a multivitamin, it requires careful consideration of your total vitamin A intake and consultation with a healthcare professional. Your health and safety should always come first, and managing your vitamin intake while on isotretinoin is crucial to avoid potential complications.

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