Managing Neuropathy: Concerns About B12 and Vitamin Overdose - Neurology

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Myasthenia Gravis, medication issues?


Hello Doctor: I previously experienced lumbar disc protrusion with lower back pain and ankle numbness.
The doctor prescribed Methylcobalamin (B12) for nerve maintenance, but it doesn't seem to be effective.
Is this considered a high-dose formulation? If I also take a B-complex vitamin supplement, will that lead to an overdose? Recently, I have been experiencing persistent numbness and loss of sensation in both legs, from the ankles to the calves, which has not subsided.
Can taking Methylcobalamin help improve this condition? Thank you.

Xiao An, 30~39 year old female. Ask Date: 2022/11/28

Dr. Peng Shiwei reply Neurology


Hello, in response to your inquiry, I can address it in two parts:
1.
Can vitamin B complex be taken in excess? It is true that doctors often prescribe high doses of B12, but vitamins B and C are water-soluble vitamins.
If the body takes in excess amounts, they are usually excreted through urine.
Therefore, unless there are concerns regarding your kidney function, the likelihood of excess is low.
2.
Worsening symptoms of numbness in both calves: If both sides are experiencing numbness, it may be advisable to have a physician evaluate for potential peripheral nerve damage.
Based on the diagnosis, further treatment options can be determined.

Reply Date: 2022/11/28

More Info


Managing neuropathy, especially when it involves concerns about vitamin B12 and potential vitamin overdose, requires a nuanced understanding of both the benefits and risks associated with vitamin supplementation.
Vitamin B12, also known as cobalamin, plays a crucial role in maintaining the health of nerve cells, producing DNA, and forming red blood cells. It is particularly important for neurological function, and deficiencies can lead to symptoms such as numbness, tingling, and cognitive disturbances. In your case, where you have been prescribed methylcobalamin (commonly referred to as "彌可保" in Taiwan) for nerve health, it is essential to understand the dosage and its implications.

Methylcobalamin is often used in higher doses for treating neuropathy, and it is generally considered safe even at elevated levels because it is a water-soluble vitamin. This means that excess amounts are typically excreted through urine rather than stored in the body, reducing the risk of toxicity. However, while high doses of B12 are usually well tolerated, it is still important to monitor your overall intake, especially if you are also taking a B-complex supplement.

When considering the combined intake of methylcobalamin and a B-complex vitamin, it is crucial to check the specific dosages of each vitamin. For instance, if your B-complex contains B6, B12, and other B vitamins, you should ensure that the total intake does not exceed the recommended dietary allowances (RDAs) for these vitamins. For adults, the RDA for B12 is about 2.4 micrograms per day, but therapeutic doses can be much higher, especially in the context of treating deficiencies or neuropathy.

Regarding your symptoms of persistent numbness and tingling in your legs and ankles, it is important to consult with your healthcare provider. These symptoms could indicate a range of issues, including nerve compression, circulation problems, or even side effects from medications. While methylcobalamin can support nerve health, it may not be a standalone solution for underlying conditions causing neuropathy.
In addition to vitamin supplementation, consider other aspects of your health that could be contributing to your symptoms. For example, maintaining a healthy diet rich in essential nutrients, engaging in regular physical activity, and managing stress can all play significant roles in nerve health. Furthermore, if you have a history of lumbar disc issues, physical therapy or specific exercises may be beneficial in alleviating pressure on the nerves.

If you are concerned about the potential for vitamin overdose, particularly with B vitamins, it is advisable to keep track of your dietary intake and consult with a healthcare professional who can provide personalized advice based on your health history and current medications. Regular blood tests can also help monitor your vitamin levels and ensure that you are not exceeding safe limits.

In summary, while methylcobalamin can be beneficial for nerve health, it is essential to manage your overall vitamin intake carefully. Monitor your symptoms, maintain open communication with your healthcare provider, and consider a holistic approach to managing your neuropathy that includes both supplementation and lifestyle modifications.

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