HPV Screening: Discrepancies Between Virus Types and Lesions - Obstetrics and Gynecology

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The HPV screening results show a discrepancy between the viral type and the lesion?


In July of this year, I discovered a protrusion on my vulva.
After consulting a doctor, it was suspected to be genital warts, and I was prescribed Aldara (imiquimod) to apply.
Within a week, it disappeared and healed, but to be cautious, I had a biopsy done (there was also a suspicious lesion inside the vagina, which was sent for examination).
The results confirmed the diagnosis.
Later, I underwent HPV screening and a Pap smear, which indicated that I have the high-risk HPV type 58, but no low-risk types commonly associated with genital warts.
Recently, I felt a small protrusion at the previous lesion site, and after applying Aldara a few times, it disappeared again.
Therefore, I would like to ask: 1.
Why does the report show no low-risk HPV types associated with genital warts while I have visible lesions? 2.
If I only have the high-risk HPV type 58, can it be transmitted to my sexual partner? (Since the lesions healed, I have had a single sexual partner and practiced safe sex.)

A Fang, 20~29 year old female. Ask Date: 2022/12/07

Dr. Zhang Kunmin reply Obstetrics and Gynecology


Hello, based on your description, you can have another HPV test and confirm the biopsy report with your treating physician.
If HPV is still present, there is a possibility of transmission through intimate contact.
Thank you! Wishing you peace and health, Dr.
Chang.

Reply Date: 2022/12/07

More Info


Understanding the complexities of HPV (Human Papillomavirus) screening and its implications for both individual health and sexual partners is crucial, especially in light of your recent experiences with lesions and HPV testing. Let's address your questions systematically.

1. Why does the report show no low-risk HPV types associated with warts (condyloma) while there are visible lesions?
The presence of visible lesions, such as warts, typically indicates an infection with low-risk HPV types, most commonly HPV 6 and 11. However, it's important to note that HPV testing can sometimes yield false negatives, especially if the viral load is low or if the sample was not taken from the exact area where the lesions are present. Additionally, lesions can sometimes be caused by other factors, such as irritation or other skin conditions, which may not be related to HPV at all. In your case, the lesions you experienced may have been transient or related to a different viral or dermatological condition that resolved with treatment, such as the application of the topical medication you mentioned (likely imiquimod or similar).

2. If I only have the high-risk HPV type 58, will it transmit to my partner?
High-risk HPV types, including HPV 58, are primarily associated with the development of cervical and other anogenital cancers rather than warts. While these types can be transmitted through sexual contact, they do not typically cause visible lesions like low-risk types do. If you have been diagnosed with high-risk HPV but have no visible lesions, it is still possible to transmit the virus to your partner, albeit the risk is generally lower than with low-risk types. It’s important to maintain open communication with your partner about your HPV status and to consider regular screenings for both of you, as HPV can remain dormant and asymptomatic for long periods.

Additional Considerations:
- Regular Screening: Since you have a history of HPV and lesions, it is essential to continue regular screenings, including Pap smears and HPV testing, as recommended by your healthcare provider. This will help monitor any changes in your cervical health and detect any potential issues early.


- Vaccination: If you haven't already, consider discussing the HPV vaccine with your healthcare provider. The vaccine can protect against the most common high-risk HPV types and may help reduce the risk of future infections.

- Partner Testing: It may also be beneficial for your partner to undergo HPV testing or screening, especially if there are concerns about transmission. While there is no specific test for HPV in men, a healthcare provider can evaluate any symptoms or concerns.

- Safe Practices: Continue practicing safe sex, including the use of condoms, which can reduce the risk of HPV transmission, although they do not provide complete protection since HPV can be present in areas not covered by condoms.

In conclusion, while the presence of high-risk HPV types can be concerning, understanding the nature of the virus, its transmission, and the importance of regular monitoring can help manage your health effectively. Always consult with your healthcare provider for personalized advice and follow-up care tailored to your specific situation.

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