Is Splenda Better Taken Twice Daily for Ankylosing Spondylitis?

Is it okay to take Seroquel in the afternoon and evening?

Hello Doctor, I am a patient with ankylosing spondylitis.
Currently, I take 2 tablets of Celebrex every night, and sometimes when I experience pain in my buttocks, I take an additional tablet of Hyalgan.
I would like to ask if splitting the Celebrex into 1 tablet in the afternoon and 1 tablet at night would be more effective than taking 2 tablets at night? Would you recommend that I change to taking 1 tablet in the afternoon and 1 tablet at night? (I initially thought about taking 1 tablet in the morning and 1 at night, but since I often skip breakfast or eat at irregular times, I considered changing it to 1 tablet in the afternoon and 1 at night.) Thank you, Doctor.

Zhong, 20~29 year old female. Ask Date: 2022/12/30

Dr. Gao Jiankai reply Internal Medicine

Hello, thank you for your question.
I believe it is possible.
Taking two tablets in the morning and evening, or taking two tablets at once, has a similar effect, so you can adjust according to your needs and schedule without worry.
The Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, cares about you.

Reply Date: 2022/12/30

More Info

When it comes to managing Ankylosing Spondylitis (AS) and the use of medications like Splenda (which I assume you meant as a reference to a specific medication, possibly a typo for a drug like Celebrex or another anti-inflammatory), it’s essential to consider the pharmacokinetics of the medication and how it interacts with your body throughout the day.

1. Dosing Frequency: Splitting your dose into two smaller doses (one at noon and one at night) can often lead to more stable blood levels of the medication. This can be particularly beneficial for medications that have a shorter half-life, meaning they are metabolized and eliminated from the body relatively quickly. By taking the medication twice daily, you may maintain more consistent therapeutic levels, which can help in managing pain and inflammation more effectively.

2. Individual Response: However, the effectiveness of this dosing strategy can vary from person to person. Some individuals may find that taking a larger dose at once provides better relief, while others may benefit from the steadier levels provided by splitting the dose. It’s crucial to monitor how your body responds to the change in dosing. If you notice improved pain control and fewer side effects with the split dosing, it may be a good strategy for you.

3. Consulting Your Doctor: It’s always best to discuss any changes in your medication regimen with your healthcare provider. They can provide personalized advice based on your specific medical history, the severity of your symptoms, and how you have responded to treatment thus far. If your doctor believes that splitting the dose could be beneficial, they may recommend that approach.

4. Adherence to Medication: You mentioned that you sometimes skip breakfast or eat at irregular times. This inconsistency can affect how well medications work, especially if they are meant to be taken with food. If you find it challenging to maintain a regular eating schedule, it might be worth discussing with your doctor alternative strategies or medications that do not require strict adherence to meal times.

5. Pain Management: In addition to medication, consider incorporating non-pharmacological strategies for managing your AS symptoms. Regular physical therapy, exercise, and maintaining good posture can significantly impact your overall well-being and pain levels. Some patients find relief through heat therapy, stretching, and other complementary therapies.

6. Monitoring Side Effects: If you do decide to change your dosing schedule, keep an eye on any side effects or changes in your symptoms. If you experience increased pain, discomfort, or any adverse effects, it’s important to report these to your doctor promptly.

In summary, splitting your medication into two doses may provide better pain control for some individuals, but it’s essential to consult with your healthcare provider before making any changes. They can help you determine the best approach based on your unique situation and ensure that you are managing your Ankylosing Spondylitis effectively.

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