Medication Safety During Breastfeeding: Impact on Infants - Pediatrics

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Hello, doctor.
I am currently breastfeeding and have been diagnosed with urticaria.
After visiting a dermatologist, I was prescribed oral medications including Demine, Decadron 0.5mg, Tagamet, Loratadine, and Methylprednisolone.
I would like to know if these medications will affect my 2-month-old child.

Niming, 30~39 year old female. Ask Date: 2023/02/07

Dr. Xiao Kaiwen reply Pediatrics


According to verified information: breastfeeding mothers can use Demine, while there is no research on the use of Loratadine and Decadron 0.5mg in breastfeeding mothers.
Tagamet and METHYL-PREDNISOLONE may be excreted in breast milk, so breastfeeding mothers should avoid using them.

Reply Date: 2023/02/07

More Info


When it comes to medication safety during breastfeeding, it is crucial to understand how various medications can affect both the mother and the infant. In your case, you have been prescribed several medications for urticaria (hives), including Demine, Decadron (0.5 mg), Tagamet, Loratadine, and Methylprednisolone. Each of these medications has different implications for breastfeeding mothers and their infants.

1. Demine (Diphenhydramine): This is an antihistamine that is commonly used to relieve allergy symptoms. According to available research, it is generally considered safe for breastfeeding mothers. However, it can cause sedation in both the mother and the infant, so it is advisable to monitor the baby for any signs of increased drowsiness.

2. Decadron (Dexamethasone): This is a corticosteroid that can be used to reduce inflammation. Studies suggest that low doses of dexamethasone are compatible with breastfeeding. The amount that passes into breast milk is minimal, and it is unlikely to have any significant effects on the infant when taken at prescribed doses. However, prolonged use or high doses should be approached with caution, and it is best to consult with your healthcare provider regarding the duration of treatment.

3. Tagamet (Cimetidine): This medication is used to treat conditions related to excess stomach acid. While cimetidine is generally considered safe during breastfeeding, it is important to note that it can affect the metabolism of other drugs. Therefore, if you are taking multiple medications, it is essential to discuss this with your healthcare provider to avoid potential interactions.

4. Loratadine: This is a second-generation antihistamine that is often preferred for allergy relief because it is less sedating than first-generation antihistamines. Research indicates that loratadine is safe for breastfeeding mothers and has minimal effects on the infant. It is considered one of the safer options for managing allergy symptoms during lactation.

5. Methylprednisolone: Similar to dexamethasone, methylprednisolone is a corticosteroid. The amount that enters breast milk is low, and it is generally considered safe for breastfeeding mothers. However, as with any medication, it is essential to use it under medical supervision, especially if you are on a higher dose or prolonged therapy.

In summary, while the medications you have been prescribed are generally considered safe for breastfeeding mothers, it is always best to consult with your healthcare provider regarding any concerns. Monitoring your infant for any unusual symptoms or changes in behavior is also important. If you notice any signs of sedation or other adverse effects in your baby, you should contact your pediatrician immediately.

Additionally, it is important to maintain open communication with your healthcare provider about your breastfeeding journey and any medications you are taking. They can provide personalized advice based on your specific situation and ensure that both you and your baby remain healthy during your treatment. Always prioritize your health and well-being, as it directly impacts your ability to care for your infant.

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