Declining GFR: Is It a Sign of Kidney Issues? - Family Medicine

Share to:

Health check-up issues


Hello, doctor.
I would like to ask if my glomerular filtration rate (GFR) is considered to be declining.
I am 32 years old, and for the past few years, my GFR has been around 120.
Last January, it was 99, and when I tested again in August, it was 94.
Is this decline indicative of kidney problems, or is it normal for GFR to fluctuate? I am quite worried about it continuously decreasing.
The health check report states that a GFR below 90 will be marked in red.
I recall that during this period, I started taking medication after undergoing surgery for a chocolate cyst (endometriosis), and I have been on medication for over a year (Dienogest).
Two months after starting the medication, my GFR was 108, and after a year, it was 99 in January and 94 in August.
Could the medication be affecting my kidney function? If I stop the medication, will my GFR return to normal? Thank you.

LALA, 30~39 year old female. Ask Date: 2023/02/09

Dr. Lin Zhebin reply Family Medicine


Hello: The normal glomerular filtration rate (GFR) is typically between 100-120 mL/min.
After the age of 30-40, it generally declines by about 1 mL/min each year.
This value is primarily calculated based on the serum creatinine level, along with age and gender, but can also be influenced by other factors such as dehydration, infection, and inflammation.
In addition to GFR, kidney function assessment also considers blood urea nitrogen (BUN) and creatinine levels, urine tests for proteinuria, and renal ultrasound for a comprehensive evaluation.
Furthermore, the medication Etoposide usually does not affect kidney function.
In summary, it is recommended that you consult a nephrologist for further examination and assessment regarding the decline in your GFR.

Reply Date: 2023/02/09

More Info


Understanding the implications of a declining glomerular filtration rate (GFR) is crucial for assessing kidney health. GFR is a key indicator of kidney function, measuring how well your kidneys filter blood. A normal GFR typically ranges from 90 to 120 mL/min/1.73 m², and values below 90 can indicate potential kidney issues.

In your case, you mentioned that your GFR was around 120 in previous years, but it has declined to 99 in January of last year and further to 94 in August. This downward trend can indeed be concerning, especially since you are only 32 years old. While fluctuations in GFR can occur due to various factors, a consistent decline warrants further investigation.

Several factors can contribute to changes in GFR, including medications, underlying health conditions, hydration status, and dietary habits. You mentioned that you have been taking medication for endometriosis (likely a hormonal treatment) since your surgery. Some medications can affect kidney function, either directly or indirectly. For instance, certain pain relievers, diuretics, and some medications used for chronic conditions can impact kidney health. It is essential to discuss with your healthcare provider whether the medication you are taking could be influencing your GFR.

Additionally, hydration plays a significant role in kidney function. Dehydration can lead to a temporary decrease in GFR, while adequate hydration can help maintain it. If you have experienced changes in your fluid intake or dietary habits, these could also be contributing factors.

Regarding your concern about the GFR dropping below 90, it is important to note that while a GFR below 90 is often flagged as a potential issue, it does not automatically indicate kidney disease. The context of the decline, including any symptoms you may be experiencing, your overall health, and any other laboratory findings, should be considered.
If you are worried about the continued decline in your GFR, it would be prudent to consult a nephrologist (kidney specialist). They can conduct a thorough evaluation, which may include additional blood tests, urine tests, and possibly imaging studies to assess kidney structure and function. They can also help determine if your medication needs to be adjusted or if further interventions are necessary.

In summary, while a declining GFR can indicate potential kidney issues, it is essential to consider the broader context, including medication effects, hydration status, and overall health. Regular monitoring and open communication with your healthcare provider are key to managing your kidney health effectively. If you have any additional symptoms or concerns, do not hesitate to seek medical advice promptly.

Similar Q&A

Understanding Declining GFR: When to See a Nephrologist?

I would like to inquire about my health check report. My glomerular filtration rate (GFR) is 78, creatinine is 1.09, blood urea nitrogen (BUN) is 13.2, and uric acid is 4.9. All other reports are normal, and there is no presence of protein in the urine test. Given my age, the GFR...


Dr. Wu Hongjie reply Internal Medicine
Hello: The glomerular filtration rate (GFR) is a variable value. If the GFR is <60 ml/min and persists for more than three months, the likelihood of a diagnosis of renal failure is high. If the GFR is >60 and there are no other pathological findings (such as renal biopsy), ...

[Read More] Understanding Declining GFR: When to See a Nephrologist?


Understanding Urinary Issues: Causes and Kidney Health Concerns

Hello Doctor, I previously inquired about frequently needing to use the restroom, but it has improved. However, I have noticed that in the past few days, my urine flow has decreased and become slower (the volume of urine has also decreased), and it seems like I drip a few drops a...


Dr. Du Shixi reply Urology
Hello: 1. Could a decrease in urine flow and slow urination be due to insufficient water intake or excessive sweating? Or could it be caused by a blockage, etc.? -- If there are no injuries or infections, the likelihood is low. 2. Could slow and reduced urine flow upon waking ...

[Read More] Understanding Urinary Issues: Causes and Kidney Health Concerns


Understanding Kidney Decline: Managing Hypertension and eGFR Changes

I am 40 years old and was diagnosed with hypertension (>180) in August. My creatinine level was 1.8, and my eGFR was 44. After starting treatment with antihypertensive medication (Amlodipine) and Pentoxifylline, my creatinine level improved to 1.41 and eGFR to 59 two months ag...


Dr. Wu Jiyu reply Internal Medicine
Based on your inquiry, it is evident that you have a certain understanding of the estimated glomerular filtration rate (eGFR). Currently, your greatest risk factor is hypertension. Caring for your kidneys is a lifelong commitment, so it is essential to control your blood pressure...

[Read More] Understanding Kidney Decline: Managing Hypertension and eGFR Changes


Understanding Kidney Function Decline in Healthy Aging Adults

Hello, doctor. I have come to inquire about some related issues that my friends and family have been experiencing. The patient is a 55-year-old female who maintains a healthy diet (primarily whole foods, with minimal intake of refined, high-sugar, and high-fat foods). She does no...


Dr. Wu Hongjie reply Internal Medicine
eGFR 60-70, with no proteinuria, kidney function decline may be attributed to age factors. A low-phosphorus diet currently benefits those in stage 3 (GFR < 60) and it remains inconclusive whether implementing it earlier has advantages.

[Read More] Understanding Kidney Function Decline in Healthy Aging Adults


Related FAQ

Renal Dysfunction

(Internal Medicine)

Chronic Kidney Disease

(Urology)

Urine Report

(Family Medicine)

Hypertension

(Family Medicine)

Hypokalemia

(Family Medicine)

Edema

(Family Medicine)

Kidneys

(Traditional Chinese Medicine)

Kidney

(Nutrition)

Kidney

(Pediatrics)

Protein In Urine

(Family Medicine)