Can I Take Red Yeast Rice with Cholesterol-Lowering Medication? - Pharmacology

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Can red yeast rice from my family home be taken together with Shoumei cholesterol-lowering medication?


I used to buy health supplements like red yeast rice from my family’s brand, but recently someone recommended that I see a traditional Chinese medicine doctor.
The doctor prescribed a medication called Shoumei for lowering cholesterol.
Can I still take the red yeast rice I used to consume?

A-Zhe, 40~49 year old female. Ask Date: 2023/03/20

Dr. Huang Shenggang reply Pharmacology


Hello, A-Zhe: First of all, thank you for your question.
Regarding the red yeast rice from my maternal family, it has obtained the Ministry of Health and Welfare's health food certification, which can effectively regulate blood sugar and blood lipids.
Animal studies have confirmed that continuous consumption can help lower total cholesterol (TC), reduce triglycerides (TG), decrease low-density lipoprotein (LDL), increase high-density lipoprotein (HDL), and regulate blood sugar levels.
"Shoumei Jiangzhi" is a medication used for patients with hypercholesterolemia and hypertriglyceridemia, recommended for adults to take 1 capsule twice daily after meals, in the morning and evening.
It is not advisable to use them simultaneously!

Reply Date: 2023/03/20

More Info


When it comes to managing high cholesterol levels, many individuals explore various dietary supplements, including red yeast rice (RYR). Red yeast rice is a fermented product made by culturing rice with a specific type of yeast, Monascus purpureus. It contains monacolin K, which is chemically identical to lovastatin, a prescription medication used to lower cholesterol. Given your situation, where you are currently taking a cholesterol-lowering medication prescribed by a physician, it is essential to approach the use of red yeast rice with caution.

The primary concern with combining red yeast rice and statin medications is the potential for additive effects, which can increase the risk of side effects. Both red yeast rice and statins work by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol synthesis in the liver. While this mechanism can be beneficial for lowering cholesterol levels, it can also lead to similar side effects associated with statins, such as muscle pain, liver damage, and digestive issues.

In your case, since you mentioned that you are taking a specific product called "Shou Mei Jiang Zhi," which contains red yeast rice, it is crucial to consult your healthcare provider before continuing to take your previous red yeast rice supplement. Your physician can provide personalized advice based on your overall health, current medications, and cholesterol levels. They may recommend monitoring your liver function and muscle health if you decide to take both products.

Moreover, it is essential to consider the quality and source of the red yeast rice supplement. Not all red yeast rice products are created equal; some may contain varying levels of monacolin K, and others may have contaminants or additives that could pose health risks. Therefore, choosing a reputable brand that adheres to safety standards is vital.

In addition to supplements, lifestyle modifications play a significant role in managing cholesterol levels. A heart-healthy diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can help improve your cholesterol profile. Regular physical activity, maintaining a healthy weight, and avoiding tobacco smoke are also crucial components of cardiovascular health.

If you experience any side effects or have concerns about your cholesterol management, it is vital to communicate with your healthcare provider. They can help you navigate the complexities of cholesterol-lowering strategies, including the use of supplements like red yeast rice.

In summary, while red yeast rice can be an effective natural supplement for lowering cholesterol, it should be approached with caution, especially when combined with prescription medications. Always consult your healthcare provider before making any changes to your supplement regimen, and focus on a holistic approach to managing your cholesterol through diet, exercise, and lifestyle changes.

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