Can Oral Medication Cure Gonorrhea Without Injections? - Urology

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Will taking oral medication be effective without injections?


Hello doctor, at the end of February, I had unprotected sexual intercourse with my partner.
A week before that, she had a gynecological examination and was diagnosed with vulvovaginitis.
During our intercourse, she experienced a significant amount of vaginal discharge, and she also had lower abdominal pain, painful urination, and back pain.
A week later, she went to the emergency room and was diagnosed with a kidney infection, for which she received injections and medication.
After that, she had no significant symptoms.
However, I then developed purulent discharge and was tested, confirming a diagnosis of gonorrhea.
I received two injections and recovered.
My partner, after completing her medication, had no symptoms and only went for testing in mid-March.
The results came back negative in early April.

Can gonorrhea be treated effectively with oral medication, or is it necessary to receive injections for a complete cure? Does the negative test result have any implications? Is there no possibility that she transmitted the infection to me? Thank you, doctor.

eason, 10~19 year old female. Ask Date: 2023/04/07

Dr. Du Shixi reply Urology


Hello: Gonorrhea can be treated with medication, and it is not always necessary to receive an injection.
However, the incubation period is approximately 1 day to 2 weeks.
If symptoms occur after more than a month of sexual activity, it may not necessarily be gonorrhea; it could be a urinary tract infection.
It is advisable to practice safe sex and seek medical evaluation and analysis at a hospital.
Wishing you good health.

Reply Date: 2023/04/07

More Info


Gonorrhea, caused by the bacterium Neisseria gonorrhoeae, is a sexually transmitted infection (STI) that can affect both men and women. Treatment for gonorrhea typically involves antibiotics, and the choice of medication can vary based on the severity of the infection and the patient's medical history.
In recent years, the Centers for Disease Control and Prevention (CDC) has recommended dual therapy for gonorrhea, which typically includes an injection of ceftriaxone and oral azithromycin. This combination is effective in treating the infection and helps prevent the development of antibiotic resistance. However, it is important to note that while oral medications can be effective in treating gonorrhea, they are generally not the first-line treatment for this infection, especially in cases of complicated or disseminated gonorrhea.

In your case, it appears that you received an injection for your gonorrhea treatment, which is consistent with current medical guidelines. The fact that your partner tested negative after treatment suggests that the antibiotics were effective in clearing the infection. It is also possible for one partner to be asymptomatic while still carrying the infection, which can lead to transmission. Therefore, it is crucial for both partners to be treated simultaneously to prevent reinfection.

Regarding your question about whether oral medication alone can cure gonorrhea, the answer is that while it can be effective in some cases, the standard treatment often involves injections, particularly for more severe cases. If a patient is treated with oral antibiotics alone, it is essential to ensure that the specific antibiotic used is effective against the strain of gonorrhea present, as some strains have developed resistance to certain antibiotics.

It is also important to consider follow-up testing after treatment. The CDC recommends retesting for gonorrhea three months after treatment, especially if you have new or multiple sexual partners. This is to ensure that the infection has been fully cleared and to monitor for any potential reinfection.

In summary, while oral medications can be part of the treatment for gonorrhea, they are not always sufficient on their own, particularly in more complicated cases. The use of injections, as you experienced, is often necessary to ensure effective treatment. It is crucial for both partners to be treated and to follow up with testing to confirm that the infection has been resolved. If you have any further concerns or symptoms, it is advisable to consult with a healthcare provider for personalized medical advice and treatment options.

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