Concerns About Long-Term Fish Oil Use for Depression Treatment - Psychiatry

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I would like to ask the doctor about fish oil?


Hello Doctor,
I would like to ask you some questions regarding fish oil.
For the past six months, I have been taking fish oil (1000 mg daily) due to my depression.
I'm concerned about whether long-term high-dose fish oil consumption could lead to any issues.
I found online that long-term use might result in a deficiency of vitamin E and could potentially cause symptoms like paresthesia.
Additionally, I take two capsules of Lingzhi (Reishi mushroom) daily, which my mother bought for me.
I take the Lingzhi on an empty stomach in the morning, the fish oil after lunch, and a 50 mg capsule of Jianfu after dinner.
I apologize for bothering you, and thank you for your help!

A Guo, 40~49 year old female. Ask Date: 2023/04/13

Dr. Xue Gengming reply Psychiatry


It is advisable to discuss the above situation further with your attending physician.
Thank you, and wishing you good health!

Reply Date: 2023/04/13

More Info


When it comes to the long-term use of fish oil for treating depression, there are several important considerations to keep in mind. Fish oil, which is rich in omega-3 fatty acids, has been studied for its potential benefits in managing depression and other mood disorders. However, like any supplement or medication, it is essential to understand both its benefits and potential risks.

Firstly, the dosage you mentioned—1000 mg of fish oil daily—is generally considered safe for most individuals. Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been shown to have anti-inflammatory properties and may help improve mood and cognitive function. Some studies suggest that higher doses may be beneficial for individuals with depression, but it is crucial to consult with a healthcare provider before increasing your dosage.

Regarding your concern about vitamin E deficiency, it is true that fish oil can lead to a depletion of vitamin E in the body. This is because omega-3 fatty acids can increase the oxidative stress in cells, which vitamin E helps to mitigate. However, this is typically only a concern with very high doses of fish oil (usually above 3000 mg per day). At your current dosage, it is unlikely that you would experience significant vitamin E deficiency. Nonetheless, it may be beneficial to ensure you are getting enough vitamin E through your diet or consider a supplement if advised by your healthcare provider.

As for the concern about "ant crawling syndrome," this is not a commonly recognized side effect of fish oil. However, some individuals may experience gastrointestinal discomfort, such as nausea or diarrhea, particularly when starting fish oil supplements. If you experience unusual sensations or symptoms, it is essential to discuss these with your doctor.

You also mentioned taking Lingzhi (Reishi mushroom) alongside fish oil. Lingzhi is often used in traditional medicine for its potential health benefits, including immune support and stress relief. Generally, there are no known adverse interactions between fish oil and Lingzhi; however, both can have blood-thinning effects. If you are taking other medications or have any bleeding disorders, it is crucial to consult with your healthcare provider to ensure that combining these supplements is safe for you.

Lastly, while fish oil can be a helpful adjunct in managing depression, it should not replace conventional treatments such as psychotherapy or prescribed antidepressants. It is essential to maintain open communication with your healthcare provider about your mental health treatment plan, including any supplements you are taking. Regular follow-ups can help monitor your progress and make necessary adjustments to your treatment.

In summary, long-term use of fish oil at a dosage of 1000 mg per day is generally considered safe and may offer benefits for depression. However, it is essential to monitor for any potential side effects, ensure adequate vitamin E intake, and discuss any concerns with your healthcare provider. Combining fish oil with other supplements like Lingzhi should also be done cautiously, particularly if you are on other medications. Always prioritize a comprehensive approach to managing depression that includes professional guidance and support.

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