Pain After Taking Acetaminophen: Causes and Concerns - Neurology

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Feeling unwell after taking Panadol?


Hello doctor, I experienced severe pain during my menstrual period that prompted me to buy medication from the pharmacy.
The pain reliever I took contained acetaminophen.
When I took the first pill, it didn't provide much relief.
After about four hours, I took a second pill, and then I experienced pain at the junction of my ear and jaw, numbness in my tongue, pain inside my eyes, and almost the entire right side of my head was hurting.
I have had a few experiences where taking Tylenol, which contains acetaminophen, resulted in similar symptoms.
I researched online and would like to know if this is related to the central nervous system or if it could be caused by vasodilation.
If it's not related to those, what else could be causing these symptoms?

XH, 20~29 year old female. Ask Date: 2023/04/29

Dr. Jiang Junyi reply Neurology


Hello, miss: I'm not sure which medication you are taking and what additional ingredients it contains.
Allergic reactions to acetaminophen are rare; most cases are caused by other combination medications.
1.
Cold medications: These may contain multiple ingredients, and it's uncertain which specific type is causing the allergy.
2.
Pain relievers: These could be NSAIDs (non-steroidal anti-inflammatory drugs), which are commonly associated with allergic reactions, such as EVE from Japan or ibuprofen.
3.
Extra Strength Tylenol: This contains acetaminophen and caffeine.
Thank you for your inquiry, and feel free to discuss any related questions! Wishing you good health and peace.
Dr.
Jiang Junyi, Taoyuan Medical Center, cares about you.

Reply Date: 2023/04/29

More Info


Acetaminophen, commonly known as paracetamol, is a widely used analgesic and antipyretic medication. It is often prescribed for pain relief and fever reduction. However, as with any medication, it can have side effects and may not be suitable for everyone. Your experience of pain after taking acetaminophen raises several important points regarding its use, potential side effects, and the underlying causes of your symptoms.

Firstly, it is essential to understand that acetaminophen works primarily in the central nervous system to alleviate pain and reduce fever. It is believed to inhibit the synthesis of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever. However, the exact mechanism of action is not fully understood.
In your case, the symptoms you describe—pain in the ear and jaw area, tongue numbness, and pain in the right side of your head—are unusual and may not be directly related to acetaminophen itself. While acetaminophen is generally well-tolerated, some individuals may experience adverse reactions, including allergic reactions or hypersensitivity. However, these reactions are rare and typically manifest as skin rashes or gastrointestinal issues rather than the neurological symptoms you are experiencing.

The pain you are feeling could be attributed to several factors. One possibility is that the pain is a result of tension or muscle strain, particularly if you are experiencing menstrual cramps. The stress and discomfort associated with menstrual pain can lead to muscle tension in the neck and jaw, which might explain the pain in those areas. Additionally, if you are clenching your jaw or grinding your teeth due to discomfort, this could exacerbate the pain.

Another consideration is the possibility of a migraine or tension-type headache. Migraines can cause unilateral (one-sided) head pain and may be accompanied by other symptoms such as nausea, sensitivity to light, and tingling sensations. If you have a history of migraines, it is worth considering whether your menstrual cycle could be triggering these headaches.

Furthermore, the numbness in your tongue and the pain in your ear could suggest a more complex neurological issue. Conditions such as trigeminal neuralgia, which affects the trigeminal nerve responsible for sensation in the face, could lead to similar symptoms. However, this is less common and would require further evaluation by a healthcare professional.

In terms of your immediate concerns regarding acetaminophen, it is crucial to use it as directed and to be aware of the maximum daily dosage to avoid potential liver toxicity. If you find that acetaminophen is not providing adequate relief or if you experience adverse effects consistently, it is advisable to consult with your healthcare provider. They may recommend alternative pain relief options or further investigations to determine the underlying cause of your symptoms.

In summary, while acetaminophen is generally safe and effective for many individuals, your unique reaction warrants further exploration. It is essential to communicate your symptoms to a healthcare professional who can help identify the cause and recommend appropriate treatment. If you continue to experience these symptoms, consider keeping a diary of when they occur, their intensity, and any other associated factors, as this information can be valuable for your healthcare provider in diagnosing and managing your condition.

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