Abnormal Pap smear and HPV vaccine?
Hello, Doctor.
Three years ago, during my first Pap smear, I was informed of an abnormal result (CIN 1).
At that time, the obstetrician referred me to National Taiwan University Hospital, where the doctor indicated that they could see the lesion near the cervix and performed a biopsy, confirming the presence of a high-risk HPV strain.
The doctor recommended a cone biopsy, but I did not proceed with the surgery due to family objections.
This year, I had another Pap smear, which showed only mild inflammation and no other abnormalities.
Should I consider getting the HPV vaccine in this situation? If the Pap smear missed a lesion, could there still be cellular changes? Would the HPV vaccine still be effective under these circumstances, or would it be better to wait until the next Pap smear shows normal results before getting vaccinated? Thank you, Doctor.
Aida, 30~39 year old female. Ask Date: 2023/05/27
Dr. Zhang Kunmin reply Obstetrics and Gynecology
Hello, based on your description, it is recommended to first undergo HPV testing.
If the result is negative, then you can proceed with the vaccination.
Thank you! Wishing you peace and health.
Dr.
Chang
Reply Date: 2023/05/27
More Info
Understanding abnormal Pap smears and the role of HPV vaccination is crucial for women's health, particularly in the context of cervical cancer prevention. Your situation highlights several important aspects of HPV (human papillomavirus) infection, cervical dysplasia, and the implications of vaccination.
Firstly, it’s essential to understand what an abnormal Pap smear indicates. A Pap smear is a screening tool used to detect precancerous changes in the cervix, which can be caused by HPV. The classification of results, such as CIN (cervical intraepithelial neoplasia), helps determine the severity of the changes. CIN1 indicates mild dysplasia, while CIN2 and CIN3 indicate moderate to severe dysplasia, respectively. Your previous diagnosis of CIN1 and the presence of high-risk HPV suggest that there was a potential for progression to more severe dysplastic changes or even cervical cancer if left untreated.
The recommendation for a cone biopsy (LEEP - Loop Electrosurgical Excision Procedure) was appropriate given the findings. This procedure not only helps in diagnosing the extent of the disease but also serves as a treatment to remove abnormal cells. However, it’s understandable that family concerns may have influenced your decision to delay the procedure.
Now, regarding your recent Pap smear showing only mild inflammation with no other abnormalities, it’s a positive sign. However, it is crucial to consider that Pap tests can sometimes miss areas of dysplasia, particularly if the sample does not adequately represent the cervical tissue. Therefore, while the recent results are encouraging, they do not entirely rule out the possibility of residual or undetected dysplastic cells.
As for the HPV vaccination, it is designed to prevent infection from the most common high-risk HPV types that cause cervical cancer. If you have already been infected with a high-risk type, such as HPV16, the vaccine will not clear the existing infection but can protect against other types of HPV that you may not have been exposed to yet. Given your history, it would be prudent to consult with your healthcare provider about the timing of the vaccination.
If your HPV test is negative, it may be beneficial to proceed with vaccination to provide protection against other HPV strains. However, if there is any uncertainty regarding the presence of dysplastic cells, it may be wise to wait until further testing confirms that your cervical health is stable before receiving the vaccine.
In summary, while your recent Pap results are reassuring, it is essential to continue monitoring your cervical health through regular screenings. Discussing your vaccination options with your healthcare provider, especially in light of your previous HPV infection and abnormal Pap results, will help you make an informed decision. Regular follow-ups and adherence to screening guidelines are key components in managing your cervical health and preventing potential complications in the future.
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