HPV Vaccine Injection Concerns: When to Seek Medical Advice? - Obstetrics and Gynecology

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Vaccine injection issues


Hello doctor, I received the first dose of the HPV vaccine on June 1st.
I had no discomfort at the time, but on June 8th, I experienced soreness, swelling, and a small lump at the injection site.
It has not improved up to now.
Is this normal? Should I just continue to observe it, or do I need to return to the clinic where I received the injection for an evaluation?

pei, 30~39 year old female. Ask Date: 2023/06/11

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please start with a warm compress.
If there is no improvement, it is recommended to return to your original unit for further evaluation.
Wishing you good health.

Reply Date: 2023/06/11

More Info


When it comes to receiving the HPV vaccine, it is essential to understand both the normal side effects and when to seek medical advice. The HPV vaccine, such as Gardasil or Gardasil 9, is designed to protect against certain strains of the human papillomavirus that can lead to cervical cancer and other HPV-related diseases. While the vaccine is generally safe and well-tolerated, some individuals may experience side effects.

In your case, experiencing soreness, swelling, and a small hard lump at the injection site a week after receiving the vaccine is not uncommon. Local reactions at the injection site, including pain, redness, and swelling, can occur in a significant number of individuals after vaccination. These symptoms typically resolve on their own within a few days to a week. However, if the symptoms persist beyond a week or worsen, it is advisable to seek medical attention.

Here are some guidelines on when to seek medical advice after receiving the HPV vaccine:
1. Persistent Symptoms: If the soreness, swelling, or lump at the injection site does not improve after a week or continues to worsen, it is a good idea to consult with a healthcare provider. They can assess whether the reaction is within the normal range or if it requires further evaluation.

2. Signs of Infection: If you notice increased redness, warmth, or discharge from the injection site, or if you develop a fever, these could be signs of an infection, and you should seek medical attention promptly.

3. Severe Reactions: Although rare, if you experience severe allergic reactions such as difficulty breathing, swelling of the face or throat, or a rapid heartbeat, you should seek emergency medical care immediately.

4. General Health Concerns: If you have any underlying health conditions or concerns about how the vaccine may affect you, it is always best to discuss these with your healthcare provider before vaccination. They can provide personalized advice based on your health history.

5. Follow-Up Appointments: If you have any doubts or concerns about the vaccination process, including the need for follow-up doses, it is wise to maintain communication with your healthcare provider. They can guide you on the appropriate timing for your next dose and any necessary precautions.

In summary, while mild soreness and swelling at the injection site are common and usually resolve without intervention, it is crucial to monitor your symptoms. If they persist or worsen, or if you experience any concerning signs, do not hesitate to contact your healthcare provider. They can provide reassurance, evaluate your symptoms, and ensure that you receive the best care possible. Additionally, remember that even after receiving the HPV vaccine, regular cervical screenings (Pap smears) are still recommended, as the vaccine does not protect against all HPV types that can cause cervical cancer.

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