Gastrointestinal and Liver Issues: Blood Test Guidelines

Blood tests for gastrointestinal or liver and kidney issues?

For the past three to four months, I have felt like there is something in my throat.
There have been several instances where I frequently feel nauseous and have the urge to vomit, but I can't.
This happens in the morning after waking up, while taking a shower, when I'm almost full, and when I turn my neck.
My stomach doesn't feel uncomfortable.
What could be the issue? Three years ago, I had a gastrointestinal endoscopy that only showed hemorrhoids.
If I need to check my liver or something similar, how many days after taking painkillers (like Tylenol) should I wait before getting blood drawn?

Hong, 20~29 year old female. Ask Date: 2023/06/15

Dr. Lin Minghui reply Gastroenterology and Hepatology

Feeling like there is something in your throat, frequently wanting to vomit, experiencing nausea without being able to vomit, could be due to gastrointestinal issues (such as gastroesophageal reflux disease, gastritis, or peptic ulcers).
It may also be related to chronic pharyngitis or laryngopharyngeal reflux, emotional issues, or autonomic nervous system dysfunction.
Rarely, it could be due to medication side effects (such as from analgesics) or endocrine problems, as well as neurological issues.
It is advisable to maintain a normal diet, avoid irritating foods, and not eat too quickly or too much.
If there are concerns about liver or kidney issues, blood tests can be conducted.
Overdosing on acetaminophen can lead to hepatotoxicity and cause liver inflammation.
The half-life of acetaminophen is 1-4 hours, and it is metabolized after about five half-lives, which is approximately one day later for blood tests.
Follow-up examinations in an outpatient setting are recommended.
Wishing you good health!

Reply Date: 2023/06/15

More Info

When it comes to understanding gastrointestinal and liver issues, blood tests play a crucial role in diagnosing and monitoring various conditions. Based on your symptoms and previous medical history, it is essential to consider several factors that could be contributing to your discomfort.

Firstly, the sensation of having something in your throat, along with nausea and vomiting, could indicate several potential issues. These symptoms can be associated with gastrointestinal reflux disease (GERD), esophageal disorders, or even anxiety-related conditions. Since you mentioned that you had a gastroscopy three years ago that only revealed hemorrhoids, it may be time to revisit your gastrointestinal health, especially if your symptoms have persisted or worsened.

Regarding blood tests, liver function tests (LFTs) are commonly performed to assess the health of your liver. These tests typically include measurements of enzymes such as alanine aminotransferase (ALT or GPT), aspartate aminotransferase (AST or GOT), alkaline phosphatase (ALP), and bilirubin levels. Elevated levels of these enzymes can indicate liver inflammation or damage, which may be due to various causes, including viral hepatitis, fatty liver disease, or alcohol-related liver disease.

In your case, if you are considering liver function tests, it is advisable to refrain from taking any medications, including pain relievers like acetaminophen (Tylenol), for at least 48 hours before the blood draw. Acetaminophen can affect liver enzyme levels, potentially leading to misleading results. Therefore, to ensure accurate test results, it is best to wait a few days after taking any medication before undergoing blood tests.

Additionally, if you are experiencing persistent nausea and discomfort, it may be beneficial to undergo imaging studies, such as an abdominal ultrasound or a CT scan, to evaluate the liver and surrounding structures. These imaging tests can help identify any abnormalities, such as gallstones, liver lesions, or signs of inflammation.

Moreover, given your history of gastrointestinal issues, it may be prudent to consult with a gastroenterologist who can provide a comprehensive evaluation and recommend further diagnostic tests if necessary. This may include repeat endoscopy or additional blood tests to check for specific conditions, such as H. pylori infection, which can cause gastritis and contribute to nausea.

In summary, your symptoms warrant a thorough evaluation of both your gastrointestinal and liver health. Blood tests are essential in this process, and it is crucial to follow guidelines regarding medication use before testing. If your symptoms persist, do not hesitate to seek medical attention, as early intervention can lead to better outcomes. Remember, your health is paramount, and addressing these concerns with a healthcare professional will provide you with the best path forward.

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