Antibiotic Resistance: A Patient's Concerns on CURAM - Internal Medicine

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Please inquire about bacterial resistance to antibiotics?


Hello Dr.
Lin, I am part of the group with a high BMI.
Between 2015 and 2019, I experienced multiple bacterial infections of the left parotid gland, and the clinic doctors treated me with CURAM.
However, the infection at the end of 2019 could not be controlled, and I was hospitalized, where I received intravenous antibiotics for two weeks before it was finally suppressed.
I would like to ask you, I suspect that the bacteria in my body have developed resistance to CURAM and other medications with the same components.
In the future, if I encounter situations that require antibiotics, such as skin infections or prophylaxis after tooth extraction, if a doctor prescribes amoxicillin or CURAM, will they likely be ineffective for me? Should I proactively inform the doctor about this medical history and request a different class of antibiotics? I am concerned about the possibility of the infection not being controlled and also worried about developing resistance to other types of antibiotics.
Thank you for taking the time to clarify this for me, and I wish you good health, peace, and happiness!

Mr. Huang, 30~39 year old female. Ask Date: 2023/07/10

Dr. Lin Wufu reply Internal Medicine


Hello: Different infections can be caused by different bacteria, so the presence of antibiotic-resistant bacteria in previous infections does not necessarily mean that future infections will also involve bacteria resistant to the same antibiotic.
If bacterial cultures can be performed during an infection, it is possible to directly confirm whether there is specific antibiotic resistance.
In most cases, if the type of bacteria causing the infection or its resistance profile cannot be identified, the general principle is to start with frontline antibiotics.
Even if you have had certain antibiotic-resistant bacteria in the past, if you refrain from using antibiotics for a period of time, those resistant bacteria often disappear on their own.
Therefore, there is no need to assume that Curam is ineffective for you.

Reply Date: 2023/07/10

More Info


Antibiotic resistance is a significant and growing concern in the medical community, particularly for patients with a history of recurrent infections. Your experience with CURAM (which contains amoxicillin and clavulanate) and the subsequent hospitalization due to an uncontrolled infection raises valid concerns about the effectiveness of antibiotics in your future treatments.

Firstly, it's important to understand that antibiotic resistance can develop when bacteria adapt in response to the selective pressure exerted by antibiotic use. This means that if a particular antibiotic is used repeatedly, the bacteria that are susceptible to that antibiotic may be killed off, while those that have developed resistance survive and proliferate. However, not all bacteria in your body will necessarily develop resistance to the same antibiotic, and different infections can be caused by different strains of bacteria. Therefore, just because you had a resistant strain in the past does not mean that all future infections will be resistant to CURAM or similar antibiotics.

In your case, if you suspect that you have developed resistance to CURAM, it is crucial to communicate this history to your healthcare provider. When you visit a doctor for a new infection, informing them about your past experiences with CURAM and your concerns about antibiotic resistance will help them make a more informed decision regarding your treatment. They may choose to conduct a culture and sensitivity test, which involves taking a sample from the infected area and testing it against various antibiotics to determine which ones are effective. This is the most reliable way to identify the appropriate antibiotic for your specific infection.

Regarding your concerns about future prescriptions of amoxicillin or CURAM, it is essential to understand that the effectiveness of these antibiotics can vary based on the type of bacteria causing the infection. If a different strain of bacteria is responsible for a new infection, it may still be susceptible to CURAM, even if previous strains were resistant. Additionally, if there has been a significant gap since your last antibiotic use, some resistant bacteria may have diminished or disappeared, allowing for the possibility of effective treatment with the same antibiotic.

As for your worry about developing resistance to other types of antibiotics, it is a valid concern. Overuse and misuse of antibiotics can lead to broader resistance patterns. However, if antibiotics are prescribed appropriately and taken as directed, the risk of developing resistance can be minimized. It is crucial to follow your healthcare provider's instructions regarding dosage and duration of antibiotic therapy.

In summary, here are some key points to consider:
1. Communicate Your History: Always inform your healthcare provider about your past antibiotic treatments and any concerns regarding resistance.

2. Culture Tests: Requesting a culture and sensitivity test can provide valuable information about which antibiotics will be effective against the bacteria causing your infection.

3. Antibiotic Use: Use antibiotics only as prescribed and avoid self-medicating or using leftover antibiotics from previous treatments.

4. Monitor Symptoms: If you experience recurrent infections, keep track of your symptoms and discuss them with your healthcare provider to explore potential underlying issues.

5. Healthy Lifestyle: Maintaining a healthy lifestyle, including a balanced diet and regular exercise, can help support your immune system and reduce the risk of infections.

By taking these steps, you can better manage your health and reduce the risk of antibiotic resistance in the future. Always prioritize open communication with your healthcare providers, as they are your best resource for navigating these concerns.

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