Concerns About Antibiotic Resistance in Children: What You Need to Know - Pharmacology

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Antibiotic concerns?


Hello, the doctor prescribed my child amoxicillin for 7 days due to concerns about sinusitis, but my child started taking it 3 days late and only took it for 4 days.
The symptoms improved a bit.
During the follow-up visit, the doctor prescribed an additional 4 days of Cero 250mg, but I forgot to inform the doctor that my child only took amoxicillin for 4 days, so the doctor assumed it was taken for the full 7 days.
I’m now wondering if switching to Cero after the incomplete course of amoxicillin could lead to antibiotic resistance?

jason, 30~39 year old female. Ask Date: 2013/09/24

Dr. Liao Lingmei reply Pharmacology


Dear: Antibiotics should be taken as prescribed by a physician, completing the entire course.
The medication has been changed from Amoxicillin to Cefaclor 250mg, indicating that the physician has assessed the need to switch to a second-line treatment.
The goal now is to resolve the current symptoms.
Whether there is antibiotic resistance will depend on the successful completion of this treatment course and whether first-line antibiotics can effectively treat any future infections.
Only then can we assess or discuss the presence of antibiotic resistance.
Wishing you all the best! Stay healthy and happy!

Reply Date: 2013/09/24

More Info


Antibiotic resistance is a significant concern in pediatric medicine, especially when it comes to the treatment of common infections like sinusitis. Your situation raises important questions about the appropriate use of antibiotics and the potential for developing resistance.

First, it's essential to understand what antibiotic resistance is. It occurs when bacteria evolve in response to the use of antibiotics, making those antibiotics less effective or ineffective against certain bacterial infections. This can happen when antibiotics are overused or misused, such as when they are prescribed for viral infections (like the common cold) or when patients do not complete their prescribed course of treatment.

In your case, your child was prescribed amoxicillin (万博黴素) for seven days but only took it for four days. While it is crucial to complete the full course of antibiotics to ensure that all bacteria are eradicated, missing a few doses or stopping early does not necessarily lead to immediate antibiotic resistance. However, it can contribute to the survival of some bacteria, which may not have been fully eliminated, potentially leading to a recurrence of the infection or the development of resistance over time.

When your doctor prescribed a second antibiotic, Cero (likely a reference to a different antibiotic), it is important to note that switching antibiotics can be appropriate if the initial treatment was not fully effective. However, the effectiveness of the second antibiotic can be influenced by the previous antibiotic use. If the bacteria causing the infection have developed resistance to amoxicillin, they may also be resistant to other antibiotics, depending on the type of bacteria involved.

To address your concern about antibiotic resistance, here are some key points to consider:
1. Communication with Healthcare Providers: Always inform your healthcare provider about any previous antibiotic treatments, including the duration and dosage. This information is crucial for them to make informed decisions about your child's treatment.

2. Completing Antibiotic Courses: It is vital to complete the entire course of antibiotics as prescribed, even if symptoms improve. This helps ensure that the infection is fully treated and reduces the risk of developing resistance.

3. Monitoring Symptoms: If your child’s symptoms do not improve or worsen after starting a new antibiotic, it is essential to follow up with your healthcare provider. They may need to reassess the situation and possibly conduct tests to identify the specific bacteria involved.

4. Preventive Measures: Encourage good hygiene practices, such as regular handwashing and avoiding close contact with sick individuals, to help prevent infections that may require antibiotic treatment.

5. Education on Antibiotic Use: Understanding when antibiotics are necessary (for bacterial infections) versus when they are not (for viral infections) can help reduce unnecessary prescriptions and the risk of resistance.

In summary, while your child's situation may not immediately lead to antibiotic resistance, it is essential to be vigilant about antibiotic use and to communicate openly with healthcare providers. If you have ongoing concerns about your child's health or the appropriateness of the prescribed medications, consider seeking a second opinion or consulting a pediatric specialist. This proactive approach will help ensure your child receives the best possible care and minimizes the risk of antibiotic resistance in the future.

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