Renal dysfunction and proteinuria issues?
In March, I underwent a medical examination due to my job (lifting heavy objects) and was found to have proteinuria (500 mg/dL), a glomerular filtration rate (GFR) of 50 mL/min, and a creatinine level of 1.6 mg/dL.
I have been receiving treatment from a traditional Chinese medicine practitioner.
In May, after work, I had another test which showed proteinuria (344 mg/dL), creatinine (1.8 mg/dL), and a GFR of 39 mL/min.
In my most recent test in July, the proteinuria level returned to normal (150 mg/dL), but the creatinine increased to 2.05 mg/dL (also after work), and the GFR decreased to 34.98 mL/min.
I have been consistently seeing both traditional Chinese medicine and Western medicine practitioners for treatment.
I would like to know if the continuous rise in creatinine levels is due to the heavy lifting associated with my job.
Li Lingxiao, 40~49 year old female. Ask Date: 2023/07/22
Dr. Lin Wuxuan reply Internal Medicine
It is recommended to consult your attending physician during your follow-up appointment.
Thank you.
Reply Date: 2023/07/22
More Info
The relationship between heavy lifting and kidney function, particularly concerning creatinine levels, is a complex one. Creatinine is a waste product generated from muscle metabolism, and its levels in the blood can be influenced by various factors, including muscle mass, diet, hydration status, and kidney function. In your case, the consistent elevation of creatinine levels alongside fluctuating urine protein levels raises important questions about kidney health.
Firstly, it is essential to understand that while heavy lifting and strenuous physical activity can lead to temporary increases in creatinine levels due to muscle breakdown, the significant and persistent elevations you are experiencing (from 1.6 to 2.05 mg/dL) suggest that there may be underlying kidney issues that need to be addressed. The normal range for creatinine is typically around 0.6 to 1.2 mg/dL, and levels above this can indicate impaired kidney function, especially when accompanied by a decrease in the glomerular filtration rate (GFR), which you reported as declining from 50 to 34.98 mL/min.
The presence of protein in the urine (proteinuria) is another critical indicator of kidney health. While your protein levels have fluctuated, the initial high levels (500 mg and then 344 mg) followed by a decrease to 150 mg, despite the rising creatinine, suggest that your kidneys may be under stress. Proteinuria can indicate damage to the kidney's filtering units (glomeruli), which can be caused by various factors, including hypertension, diabetes, or direct injury to the kidneys.
In your situation, the combination of heavy lifting and the observed kidney function changes could be contributing to the worsening of your renal status. Strenuous physical activity can lead to rhabdomyolysis, a condition where muscle fibers break down and release myoglobin into the bloodstream, which can be harmful to the kidneys. However, this is typically associated with very high levels of muscle damage, and your creatinine levels, while elevated, do not suggest acute rhabdomyolysis but rather a chronic issue.
Given your history of fluctuating kidney function and the need for ongoing treatment from both Western and traditional Chinese medicine, it is crucial to have a comprehensive evaluation by a nephrologist. They can perform additional tests, such as a kidney ultrasound or a kidney biopsy if necessary, to determine the underlying cause of your kidney dysfunction. It is also essential to monitor your blood pressure, blood sugar levels, and overall hydration status, as these factors can significantly impact kidney health.
In conclusion, while heavy lifting may contribute to temporary increases in creatinine levels, the persistent elevation you are experiencing, along with declining GFR and proteinuria, indicates that there may be more significant underlying kidney issues at play. It is vital to work closely with your healthcare providers to monitor your kidney function, adjust your treatment plan as necessary, and consider lifestyle modifications that may help protect your kidneys, such as avoiding heavy lifting, maintaining a balanced diet, and staying well-hydrated. Regular follow-ups and lab tests will be essential in managing your kidney health moving forward.
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