Concerns About Vaccine Reactions in Infants: A New Mom's Guide - Pediatrics

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Vaccine issues


Hello, doctor.
I am a very anxious new mother.
On July 1st, I took my baby to receive the 13-valent and pentavalent vaccines, with one injection in each leg (both of these were the third doses).
On the first day after the shots, there was redness and swelling, which resolved by the second day, but a small hard lump has remained.
As of July 25th, it has not disappeared, although it has gotten smaller.
I have shown it to two pediatricians, and they both said that if pressing on it does not cause the baby to cry or show pain, then it is fine and will go away with time.
However, the first two doses did not have this reaction.
The doctors mentioned that reactions can vary with each dose.
I am unsure if this is true.
How long might it take for it to disappear? Thank you, doctor.
I am quite nervous since this is my first child.

Si Si, 20~29 year old female. Ask Date: 2023/07/25

Dr. Xiao Kaiwen reply Pediatrics


The pentavalent vaccine and the 13-valent pneumonia vaccine may have a higher likelihood of side effects with subsequent doses compared to the initial doses.
This is because the immune system has already developed some memory, making reactions more pronounced later on.
Localized swelling at the injection site will gradually dissipate over time, so there is no need to worry excessively.
The duration for it to resolve can vary; however, applying a warm compress and gently massaging the area while showering may help with absorption and reduce the swelling more quickly.

Reply Date: 2023/07/25

More Info


As a new mom, it's completely understandable to feel anxious about your baby's health, especially after vaccinations. Vaccines are crucial for protecting infants from various diseases, but they can sometimes cause reactions that may be concerning for parents. Let's address your concerns regarding the reactions your baby experienced after receiving the 13-valent pneumococcal vaccine and the pentavalent vaccine.

Firstly, it's important to note that localized reactions, such as redness, swelling, or hard lumps at the injection site, are common after vaccinations. These reactions are usually mild and temporary. The fact that your baby experienced redness and swelling on the first day, which subsided but left a small hard lump, is not unusual. This hard lump, often referred to as a "vaccine bump," can occur as a result of the body's immune response to the vaccine. The immune system is activated to produce antibodies, and this process can lead to localized inflammation.

According to pediatric guidelines, these lumps can take time to resolve, often disappearing within a few days to a few weeks. In your case, since the lump has been present for about three weeks but is gradually getting smaller, this is a positive sign. The pediatricians you consulted are correct in stating that as long as your baby is not in pain when the lump is pressed and is otherwise healthy, there is typically no cause for concern. Each vaccine dose can elicit different reactions, and some children may experience more pronounced responses than others.

In terms of how long it might take for the lump to completely disappear, it can vary from child to child. Generally, if the lump is gradually decreasing in size, it may take a few more weeks to fully resolve. However, if you notice any changes such as increased redness, swelling, or if your baby starts to show signs of discomfort, it would be prudent to follow up with your pediatrician.

It's also worth mentioning that while some infants may have no reaction at all to a vaccine, others may have mild to moderate reactions. This variability is normal and reflects the individual differences in immune responses among children.
As a new mom, it's essential to keep an eye on your baby's overall health and behavior. If your baby is feeding well, sleeping normally, and meeting developmental milestones, these are good indicators that they are doing well despite the localized reaction.
In summary, localized reactions to vaccines, such as the hard lump you described, are generally benign and will resolve on their own. It's always a good idea to maintain open communication with your pediatrician and to seek their advice if you have any concerns. Remember, your instincts as a mother are important, and it's okay to ask questions and seek reassurance. Vaccination is a vital part of keeping your baby healthy, and the benefits far outweigh the temporary discomfort that may arise from these reactions.

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