Does the HPV Nine-Valent Vaccine Affect Menstrual Cycles? - Obstetrics and Gynecology

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Does the nine-valent vaccine affect the menstrual cycle?


Hello, doctor.
I apologize for bothering you, but I'm really anxious and would like to ask a question.
My menstrual cycle is usually very regular, around 29-30 days.
My last period was from July 19 to July 29.
I had sexual intercourse with my boyfriend on August 3 (with a condom, which we checked for leaks).
I’m particularly worried because on August 9, we had external genital contact without a condom, and I washed immediately afterward.
Since then, we haven’t had any sexual activity.
Today (August 19), I bought a pregnancy test from Mentholatum and confirmed one line within 10 minutes.
However, four hours later, I saw a faint second line, which made me very nervous.
I also received the second dose of the HPV vaccine on August 11, and I'm unsure if it could affect my cycle (official responses say it won’t, but I’ve seen some people on forums say it might cause a delay).
Currently, I’m experiencing premenstrual symptoms: I have premenstrual depressive symptoms (which I usually experience for two to three days each month; this time it was from August 10 to August 12), breast tenderness, and slight discomfort in my lower abdomen.

Q1: Does the HPV vaccine affect the menstrual cycle?
Q2: What is the likelihood of pregnancy given the above circumstances?
Thank you for your patience in addressing my concerns!

n, 20~29 year old female. Ask Date: 2023/08/20

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, vaccination is unrelated to menstruation, and it is likely that you are not pregnant.
Wishing you good health.

Reply Date: 2023/08/20

More Info


The concerns regarding the Nine-Valent HPV vaccine and its potential effects on menstrual cycles are quite common among individuals receiving the vaccine. Let's address your questions in detail.

Q1: Does the Nine-Valent HPV vaccine affect menstrual cycles?
Current research and clinical guidelines indicate that the Nine-Valent HPV vaccine, like its predecessors, does not have a direct impact on menstrual cycles. The vaccine is designed to protect against certain strains of the human papillomavirus (HPV) that are associated with cervical cancer and genital warts, and it does not interfere with hormonal regulation or the menstrual cycle.
However, some individuals report experiencing changes in their menstrual cycles after vaccination, which could be attributed to various factors, including stress, anxiety, or other unrelated health issues. It is important to note that while anecdotal reports exist, they do not constitute scientific evidence. The official stance from health organizations, including the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), is that the HPV vaccine is safe and does not affect menstrual cycles.

Q2: What is the likelihood of pregnancy given the circumstances described?
From your description, it seems you have been diligent about using protection during sexual intercourse, which significantly reduces the risk of pregnancy. The fact that you have taken a pregnancy test and received a negative result (with only a faint line appearing later) suggests that you are not pregnant, especially if the test was taken correctly and within the appropriate timeframe.
It is also important to consider the timing of your menstrual cycle. If your cycle is typically 29-30 days, and you are currently within that cycle, it is possible that your period may be approaching. Stress and anxiety can also affect the timing of your menstrual cycle, potentially causing delays.
Regarding the symptoms you mentioned, such as premenstrual depression, breast tenderness, and mild abdominal discomfort, these are common premenstrual symptoms and can occur regardless of vaccination status.
In summary, while the HPV vaccine does not affect menstrual cycles, it is always wise to monitor your body and consult with a healthcare provider if you notice significant changes or have ongoing concerns. If your period does not arrive as expected, or if you continue to experience unusual symptoms, it would be prudent to follow up with your healthcare provider for further evaluation.

In conclusion, while the HPV vaccine is a crucial preventive measure against certain cancers and does not interfere with menstrual cycles, it is essential to maintain open communication with your healthcare provider regarding any concerns you may have about your reproductive health. Regular check-ups and discussions about your health can provide reassurance and help address any issues that may arise.

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