Medication Safety During Pregnancy: What You Need to Know - Obstetrics and Gynecology

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Medication Information During Pregnancy


Hello, Doctor.
I am currently 12 weeks pregnant and visited an ENT specialist for a cold, who prescribed Diclofenac (25mg) to be taken three times a day.
I found online that it is classified as Category C for pregnant women.
Could this have any early effects on the baby? Additionally, I was prescribed Pelonine, Fencain, Famotidine, Cetirizine (white strip), and Noscapine.
Are there any risks associated with these medications? Thank you!

mei, 30~39 year old female. Ask Date: 2023/08/27

Dr. Chen Zhiyu reply Obstetrics and Gynecology


Please consult the prescribing physician or refer to the information on the medication bag for inquiries.
Thank you.

Reply Date: 2023/08/27

More Info


When it comes to medication safety during pregnancy, it is crucial to understand that the effects of drugs can vary significantly depending on the stage of pregnancy and the specific medication in question. As you mentioned, you are currently 12 weeks pregnant and have been prescribed several medications. Let's break down the medications you listed and their associated risks.

1. Diclofenac (25mg): This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID). The FDA categorizes it as a Class C drug during pregnancy, which means that risk cannot be ruled out. Animal studies have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in pregnant women. The use of NSAIDs, particularly in the third trimester, can lead to complications such as premature closure of the ductus arteriosus in the fetus and potential kidney issues. Therefore, it is generally advised to avoid NSAIDs during pregnancy unless absolutely necessary and prescribed by a healthcare provider.

2. Pelonine (Johnson's): Without specific details on the active ingredient, it's challenging to provide a precise risk assessment. However, it is essential to consult with your healthcare provider regarding its safety during pregnancy.

3. Fencain: This medication is often used as an antihistamine. The safety of antihistamines during pregnancy can vary. Some, like diphenhydramine, are considered relatively safe, while others may have unknown effects. It is crucial to discuss this medication with your doctor to understand its safety profile.

4. Famotidine: This is a histamine-2 blocker used to reduce stomach acid. It is classified as a Category B drug, meaning that studies in pregnant women have not shown a risk to the fetus. Famotidine is generally considered safe during pregnancy, especially for treating conditions like heartburn or gastric ulcers.

5. Cetirizine: This is an antihistamine commonly used for allergies. It is also classified as a Category B drug, indicating that it is generally considered safe for use during pregnancy. However, as with any medication, it is best to use it under the guidance of a healthcare provider.

6. Noscapine: This is a cough suppressant. The safety of noscapine during pregnancy is not well-established, and it is essential to consult your healthcare provider regarding its use.

In summary, while some medications you have been prescribed are considered relatively safe during pregnancy (like famotidine and cetirizine), others, such as diclofenac, carry potential risks that should be carefully weighed against the benefits. It is crucial to communicate openly with your healthcare provider about your concerns and any potential risks associated with the medications you are taking. They can help you make informed decisions based on your specific health needs and the health of your developing baby.

Always remember that self-medication or relying solely on internet resources for medication safety can lead to misunderstandings and potential risks. It is best to have a thorough discussion with your healthcare provider, who can provide personalized advice based on your medical history and current condition.

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