Impact of COVID-19 Vaccination on Infection Risks and Long-Term Effects - Internal Medicine

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Regarding COVID-19 vaccines?


Hello, Doctor! I would like to ask: I received my first dose of the COVID-19 vaccine (AstraZeneca) on September 10, 2021, my second dose (BioNTech) on November 24, 2021, and my booster dose (BioNTech) on March 1, 2022.
I would like to know what the outcomes would be if I do not receive any additional vaccinations and continue to live in Taiwan.
For example: 1.
Will I be at risk of developing severe illness if I get infected? (I am 29 and a half years old, with no chronic diseases, only nasal allergies and mental health issues.) 2.
If I do not receive any more vaccinations and become infected, will I experience long-term effects from COVID-19? (For instance, brain fog or other effects that could impact cognitive function.) Thank you, Doctor!

Niming, 20~29 year old female. Ask Date: 2023/10/28

Dr. Lin Wufu reply Internal Medicine


Hello, there is a certain probability of severe illness associated with COVID-19, which is related to factors such as the patient's age, pre-existing chronic conditions, and vaccination status.
Your situation indicates that the likelihood of experiencing severe illness is low, but this does not mean that it is impossible.
To enhance your safety, it is still recommended to get vaccinated.
Regarding post-COVID syndrome, past studies suggest that individuals who are not fully vaccinated have a higher incidence of these long-term effects.
Therefore, it is advisable to receive the latest XBB vaccine.

Reply Date: 2023/10/28

More Info


Hello! Thank you for your questions regarding COVID-19 vaccination and its implications for infection risks and long-term effects. Let's break down your inquiries into manageable parts.

1. Risk of Severe Disease: Given your vaccination history—having received the AstraZeneca (AZ) vaccine followed by two doses of the BNT (BioNTech) vaccine—you have a solid foundation of immunity against COVID-19. While breakthrough infections can occur, the likelihood of developing severe disease is significantly reduced in vaccinated individuals compared to those who are unvaccinated. At 29 years old and without chronic illnesses, your risk of severe illness from COVID-19 is relatively low, especially considering your vaccination status. However, it is important to remain vigilant, as the virus can still pose risks, particularly with emerging variants.

2. Long COVID Risks: The phenomenon known as "Long COVID" refers to a range of symptoms that can persist for weeks or months after the initial infection has resolved. Research indicates that vaccinated individuals who contract COVID-19 tend to experience a lower incidence of Long COVID symptoms compared to unvaccinated individuals. While there is still a risk of developing Long COVID, your vaccination status and age work in your favor. Studies suggest that vaccinated individuals are less likely to experience severe symptoms during the acute phase of the infection, which may correlate with a lower risk of long-term complications.

3. Impact of Not Receiving Additional Doses: If you choose not to receive any additional doses of the COVID-19 vaccine, your existing immunity from the three doses you have received will still provide some level of protection. However, it is important to note that immunity can wane over time, particularly against newer variants of the virus. The Centers for Disease Control and Prevention (CDC) and other health authorities recommend booster doses to enhance and prolong immunity, especially in the context of emerging variants. If you were to contract COVID-19 after a significant period without additional vaccination, your risk of severe disease and potential long-term effects may increase compared to if you had received a booster.

4. Mental Health Considerations: Regarding your concerns about mental health and potential cognitive effects such as "brain fog," it is worth noting that some individuals report cognitive difficulties following COVID-19, regardless of their vaccination status. However, the risk appears to be lower in vaccinated individuals. Maintaining good mental health practices, such as regular exercise, a balanced diet, and social engagement, can help mitigate some of these risks.

5. Recommendations: Given the evolving nature of the pandemic and the emergence of new variants, it is advisable to stay informed about vaccination recommendations in your area. If additional booster doses become available and are recommended, consider discussing them with your healthcare provider. They can provide personalized advice based on your health history and current guidelines.

In conclusion, while your current vaccination status provides a good level of protection, remaining vigilant and considering future vaccinations can help further reduce your risk of severe disease and long-term complications. Always consult with your healthcare provider for tailored advice and to address any specific concerns you may have. Stay safe and healthy!

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