HPV Infection and Pap Smear Results After Treatment - Obstetrics and Gynecology

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Pap Smear Test & HPV Infection


Hello, doctor.
In September 2021, I was diagnosed with CIN 2, and in October, I underwent a cone biopsy.
Post-operative follow-up was normal.
In June 2022, I completed the nine-valent HPV vaccine, and subsequent follow-up in September 2022 showed no abnormalities.
However, in October 2023, a Pap smear revealed an abnormal result with a value of 16.

1.
I would like to ask why, after a clean excision and vaccination, I would still experience a recurrent infection? Additionally, my boyfriend received the HPV vaccine 5-6 years ago before we started dating.

2.
Can he be infected by me before my treatment?
3.
Could I transmit the infection back to him after my treatment?
4.
Does he need to get tested?

K, 30~39 year old female. Ask Date: 2023/11/08

Dr. Lin Manying reply Obstetrics and Gynecology


Hello: 1.
Cone biopsy surgery has an inflammation rate of approximately 0.3%-0.4%.
Vaccination may lead to concerns about reinfection; vaccines are not intended to eliminate the virus but to provide prevention.
It is also possible that a previous infection was not completely cleared.
2.
Your boyfriend has received the HPV vaccine; whether you will be infected depends on his sexual history.
Additionally, your boyfriend does not need to undergo testing at this time.
Hualien Hospital, Ministry of Health and Welfare, cares about your health.

Reply Date: 2023/11/08

More Info


Understanding HPV Infection and Pap Smear Results After Treatment
Human Papillomavirus (HPV) is a common sexually transmitted infection that can lead to various health issues, including cervical cancer. The relationship between HPV, Pap smear results, and subsequent treatments can be complex, especially after a diagnosis of cervical intraepithelial neoplasia (CIN) and treatment through procedures like conization (LEEP).
In your case, you were diagnosed with CIN2 in September 2021, underwent a conization procedure in October, and received the nine-valent HPV vaccine in June 2022. Despite these interventions, you experienced an abnormal Pap smear result in October 2023. This situation raises several important questions regarding the nature of HPV infections and the effectiveness of vaccines and treatments.

1. Why might there be a recurrence of HPV infection after treatment and vaccination?
The HPV vaccine is designed to prevent new infections from specific high-risk HPV types, particularly types 16 and 18, which are associated with cervical cancer. However, the vaccine does not treat existing infections. If you were already infected with HPV prior to vaccination, the vaccine would not eliminate the virus. Additionally, there are many strains of HPV, and while the vaccine protects against the most dangerous types, it does not cover all strains. Therefore, it is possible to be reinfected with a different strain of HPV after treatment, or the initial infection may not have been completely cleared.

2. Regarding your boyfriend's vaccination status:
If your boyfriend was vaccinated against HPV before your relationship, he is less likely to contract the virus from you, especially if he received the vaccine for the same high-risk types. However, it is important to note that the vaccine is not 100% effective, and he could still be at risk if he was exposed to a strain not covered by the vaccine or if he was infected before vaccination.
3. Can he be reinfected by you after your treatment?
If you have undergone treatment and your HPV infection has been cleared, the risk of reinfection is minimal. However, if you still have an active infection, there is a possibility of transmission. It is crucial for both partners to be aware of their HPV status and to engage in open discussions about sexual health.
4. Should your boyfriend get tested?
While it is not mandatory for him to get tested, it may be beneficial. HPV testing for men is not as straightforward as it is for women, as there is no approved test for HPV in men. However, if he has any symptoms or concerns, he should consult a healthcare provider. Regular check-ups and discussions about sexual health can help both partners manage their risk.

In conclusion, the interplay between HPV, Pap smear results, and treatment is multifaceted. Vaccination is a powerful tool in preventing HPV-related diseases, but it does not replace the need for regular screenings and monitoring. It is essential to maintain open communication with your healthcare provider and your partner regarding HPV status and to follow recommended guidelines for follow-up care. Regular Pap smears and HPV testing are vital in monitoring cervical health, especially after a history of CIN.

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