HIV Testing Results: A Journey Through Two Pregnancies - Internal Medicine

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I tested positive for HIV three years ago when I had my first child (my second child). The first test was positive, while the second test was negative?


Three years ago, I had two children.
The first pregnancy tested positive in March 2019, and the second in October 2020, both being first-time positives.
I sent samples for further testing in Taipei, and both came back negative.
Since then, I have not engaged in any risky behavior or relationships.
I am now undergoing stem cell treatment and testing.
The first test came back positive, and this morning I had a second blood draw that also tested positive, using the dot blot assay.
The hospital mentioned a 50% chance.
I will have a final viral load test on Monday.
Is there a possibility of a turnaround? I am very troubled because there has been no means of transmission.

Xiao Xiao, 20~29 year old female. Ask Date: 2023/11/10

Dr. Liao Zhongxin reply Internal Medicine


1.
The first question is whether an HIV-positive baby has been born.
If so, at least one parent must be an HIV-infected individual, and regardless of whether the initial test result is negative or positive, a confirmatory test must be conducted at a hospital.

2.
What is the purpose of undergoing stem cell transplantation? Is it for the treatment of hematological diseases or malignant tumors, or for other reasons? In Taiwan, it is essential to clarify these details before proceeding with treatment.
3.
The Western blot test is a diagnostic tool with an accuracy rate approaching 100%, unless the individual has recently contracted HIV or is in the advanced stages of infection, in which case there may be ambiguous results.

Reply Date: 2023/11/10

More Info


Understanding HIV testing results can be a complex and emotional journey, especially when it involves pregnancies and potential health treatments like stem cell therapy. In your case, it appears that you have experienced a series of HIV tests over the past few years, with varying results that have understandably caused confusion and concern.

Firstly, it is important to clarify what the HIV tests indicate. The initial positive results during your pregnancies suggest that there may have been a risk of HIV transmission, either to you or your child. However, the subsequent negative results from confirmatory testing indicate that you may not be infected with HIV. This can happen for several reasons, including the possibility of false positives, which can occur due to various factors such as cross-reactivity with other infections or conditions.

The Western blot test, which is often used as a confirmatory test for HIV, is highly accurate and can help clarify any uncertainties. If your recent tests are again showing positive results, it is crucial to understand the context. The laboratory's statement of a "50% chance" likely refers to the possibility of a false positive, especially if the test results are not consistent with your previous negative tests.
In the context of HIV testing, it is essential to consider the "window period," which is the time after potential exposure during which HIV may not be detectable. Typically, antibodies to HIV can take several weeks to months to develop, and testing too early can lead to inaccurate results. Given that you have not engaged in any high-risk behaviors since your last negative test, the likelihood of a new infection is low, but it is not impossible.

As you prepare for stem cell therapy, it is vital to have a clear understanding of your HIV status. The healthcare team will likely recommend further testing, including a viral load test, which measures the amount of HIV in your blood. This test can provide more definitive information about whether you are currently infected with HIV.

If your results continue to show positive, it is crucial to discuss the implications with your healthcare provider. They can provide guidance on the next steps, including potential treatment options and how to manage your health moving forward. Additionally, if there are concerns about the accuracy of the tests, seeking a second opinion or additional testing at a different facility may provide further clarity.

In summary, while the journey through HIV testing can be fraught with uncertainty, understanding the nature of the tests, the implications of the results, and the importance of follow-up testing is essential. It is also important to maintain open communication with your healthcare providers, who can help navigate this complex situation and ensure that you receive the appropriate care and support.

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